Sökning: L773:0300 9742 OR L773:1502 7732 > Responsiveness of d...
Fältnamn | Indikatorer | Metadata |
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000 | 03707naa a2200457 4500 | |
001 | oai:gup.ub.gu.se/284411 | |
003 | SwePub | |
008 | 240528s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2844112 URI |
024 | 7 | a https://doi.org/10.1080/03009742.2019.16398202 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Axelsen, M. B.4 aut |
245 | 1 0 | a Responsiveness of different dynamic contrast-enhanced magnetic resonance imaging approaches: a post-hoc analysis of a randomized controlled trial of certolizumab pegol in rheumatoid arthritis |
264 | c 2019-09-16 | |
264 | 1 | b Informa UK Limited,c 2020 |
520 | a Objective: The aim was to explore dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as an early marker of therapeutic response in patients with rheumatoid arthritis (RA) starting treatment with certolizumab pegol (CZP). Method: In 40 RA patients initiating CZP (27 patients) or 2 weeks of placebo (PCB) followed by CZP (13 patients), DCE-MRI of the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints was performed at weeks 0, 1, 2, 4, 8, and 16. Using semi-automated software, three methods for drawing volume regions of interest (ROIs) in MCP2-5 and PIP2-5 were applied: 'Standard' (slices: all; joints: MCP2-5 together and PIP2-5 together), 'Detailed' (slices: slices with high-quality visualization; joints: as Standard), and 'Single-joint' (slices: as Detailed; joints: each joint separately). The number of enhancing voxels (Nvoxel), initial rate of enhancement (IRE), and maximum enhancement (ME) were extracted and analysed for each method. Results: Nvoxel in MCP2-5, and IRE and ME in PIP2-5 decreased statistically significantly (Wilcoxon rank-sum test, p < 0.02-0.03) after 16 weeks of treatment for the Standard method. Nvoxel and ME decreased significantly more in the CZP group than in the PCB group after 1 week of treatment, but not at later time-points. There were no significant changes for DCE-MRI parameters for the Detailed and Single-joint methods. Conclusions: Certain DCE-MRI parameters detected decreased inflammation during CZP treatment in RA patients. Using specific criteria for ROIs, as in the Detailed and Single-joint methods, decreased the statistical power and could not show any changes over time. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a bone-marrow edema | |
653 | a gadolinium-dtpa | |
653 | a mri assessment | |
653 | a synovitis | |
653 | a wrist | |
653 | a inflammation | |
653 | a progression | |
653 | a scores | |
653 | a ra | |
653 | a Rheumatology | |
700 | 1 | a Boesen, M.4 aut |
700 | 1 | a Bliddal, H.4 aut |
700 | 1 | a Jacobsson, Lennart T. H.,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xjacle |
700 | 1 | a Hansen, M. S.4 aut |
700 | 1 | a Ostergaard, M.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
773 | 0 | t Scandinavian Journal of Rheumatologyd : Informa UK Limitedg 49:2, s. 105-111q 49:2<105-111x 0300-9742x 1502-7732 |
856 | 4 8 | u https://gup.ub.gu.se/publication/284411 |
856 | 4 8 | u https://doi.org/10.1080/03009742.2019.1639820 |
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