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Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.
- Bersani, Francesco Saverio (author)
- Wolkowitz, Owen M (author)
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- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Yehuda, Rachel (author)
- Flory, Janine (author)
- Bierer, Linda M (author)
- Makotine, Iouri (author)
- Abu-Amara, Duna (author)
- Coy, Michelle (author)
- Reus, Victor I (author)
- Epel, Elissa S (author)
- Marmar, Charles (author)
- Mellon, Synthia H (author)
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- (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
- In: Brain Behavior and Immunity. - : Elsevier BV. - 1090-2139 .- 0889-1591. ; 52:oct 26, s. 153-160
- Journal article (peer-reviewed)
Abstract
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- Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- Makotine, Iouri
- Abu-Amara, Duna
- Coy, Michelle
- Reus, Victor I
- Epel, Elissa S
- Marmar, Charles
- Mellon, Synthia ...
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