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Sökning: WFRF:(Andersen Mikkel R.) > Injection of high d...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003828naa a2200421 4500
001oai:lup.lub.lu.se:d42176e1-cc94-44b9-8c45-a32562b75aa8
003SwePub
008171120s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/d42176e1-cc94-44b9-8c45-a32562b75aa82 URI
0247 a https://doi.org/10.1038/s41598-017-14997-32 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pingel, Jessicau University of Copenhagen4 aut
2451 0a Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures
264 c 2017-11-07
264 1b Springer Science and Business Media LLC,c 2017
520 a Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular BoNT/A injections (6 UI = 60 pg) on muscle tissue. The gait pattern of the rats was significantly affected 3 weeks after BoNT/A injection. The ankle joint rotated externally, the rats became flat footed, and the stride length decreased after BoNT/A injection. Additionally, there was clear evidence of microstructural changes on the tissue level by as evidenced by 3D imaging of the muscles by Synchrotron Radiation X-ray Tomographic Microscopy (SRXTM). Both the fibrillar and the non-fibrillar tissues were affected. The volume fraction of fibrillary tissue was reduced significantly and the non-fibrillar tissue increased. This was accompanied by a loss of the linear structure of the muscle tissue. Furthermore, gene expression analysis showed a significant upregulation of COL1A1, MMP-2, TGF-b1, IL-6, MHCIIA and MHCIIx in the BoNT/A injected leg, while MHVIIB was significantly downregulated. In conclusion: The present study reveals that high dose intramuscular BoNT/A injections cause microstructural damage of the muscle tissue, which contributes to impaired gait.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
7001 a Nielsen, Mikkel Schouu University of Copenhagen4 aut
7001 a Lauridsen, Torstenu University of Copenhagen4 aut
7001 a Rix, Kristianu University of Copenhagen4 aut0 (Swepub:lu)kr1387ri
7001 a Bech, Martinu Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mbh
7001 a Alkjaer, Tineu University of Copenhagen4 aut
7001 a Andersen, Ida Torpu University of Copenhagen4 aut
7001 a Nielsen, Jens Bou University of Copenhagen4 aut
7001 a Feidenhansl, R.u University of Copenhagen4 aut
7102 a University of Copenhagenb Medicinsk strålningsfysik, Lund4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 7:1q 7:1x 2045-2322
8564 u http://dx.doi.org/10.1038/s41598-017-14997-3x freey FULLTEXT
8564 u https://www.nature.com/articles/s41598-017-14997-3.pdf
8564 8u https://lup.lub.lu.se/record/d42176e1-cc94-44b9-8c45-a32562b75aa8
8564 8u https://doi.org/10.1038/s41598-017-14997-3

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