Novel Cruzain Inhibitors for the Treatment of Chagas' Disease

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Fältnamn	Indikatorer	Metadata
000		02542naa a2200421 4500
001		oai:DiVA.org:uu-179897
003		SwePub
008		120827s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1798972 URI
024	7	a https://doi.org/10.1111/j.1747-0285.2012.01416.x2 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Rogers, Kathleen E.4 aut
245	1 0	a Novel Cruzain Inhibitors for the Treatment of Chagas' Disease
264		c 2012-06-27
264	1	b Wiley,c 2012
338		a print2 rdacarrier
520		a The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas disease, affects millions of individuals and continues to be an important global health concern. The poor efficacy and unfavorable side effects of current treatments necessitate novel therapeutics. Cruzain, the major cysteine protease of T.similar to cruzi, is one potential novel target. Recent advances in a class of vinyl sulfone inhibitors are encouraging; however, as most potential therapeutics fail in clinical trials and both disease progression and resistance call for combination therapy with several drugs, the identification of additional classes of inhibitory molecules is essential. Using an exhaustive virtual-screening and experimental validation approach, we identify several additional small-molecule cruzain inhibitors. Further optimization of these chemical scaffolds could lead to the development of novel drugs useful in the treatment of Chagas disease.
653		a Chagas' disease
653		a computer-aided drug discovery
653		a cruzain
653		a cruzipain
653		a cysteine protease inhibitor
653		a Trypanosoma cruzi
700	1	a Keränen, Henriku Uppsala universitet,Beräknings- och systembiologi4 aut0 (Swepub:uu)henke383
700	1	a Durrant, Jacob D.4 aut
700	1	a Ratnam, Joseline4 aut
700	1	a Doak, Allison4 aut
700	1	a Arkin, Michelle R.4 aut
700	1	a McCammon, J. Andrew4 aut
710	2	a Uppsala universitetb Beräknings- och systembiologi4 org
773	0	t Chemical Biology and Drug Designd : Wileyg 80:3, s. 398-405q 80:3<398-405x 1747-0277x 1747-0285
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1747-0285.2012.01416.x
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179897
856	4 8	u https://doi.org/10.1111/j.1747-0285.2012.01416.x

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Av författaren/redakt...: Rogers, Kathleen ...; Keränen, Henrik; Durrant, Jacob D ...; Ratnam, Joseline; Doak, Allison; Arkin, Michelle ...; visa fler...; McCammon, J. And ...; visa färre...

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Av lärosätet: Uppsala universitet

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