The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia

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Fältnamn	Indikatorer	Metadata
000		05533naa a2200505 4500
001		oai:DiVA.org:uu-267485
003		SwePub
008		151124s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2674852 URI
024	7	a https://doi.org/10.1007/s00213-015-4007-x2 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Hvoslef-Eide, M.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.4 aut
245	1 0	a The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia
264		c 2015-07-24
264	1	b Springer Science and Business Media LLC,c 2015
338		a print2 rdacarrier
520		a The NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://www.newmeds-europe.com) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia. This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere. The battery consists of the five-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a three-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel non-matching to sample-based tasks for measuring spatial working memory and paired-associates learning for measuring long-term memory. The rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks. This battery of tests constitutes an extensive tool package for both model characterisation and pre-clinical drug discovery.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a Drug discovery
653		a Neuropsychiatric disease
653		a Attention
653		a Working memory
653		a Long-term memory
653		a Executive function
653		a Cognitive flexibility
653		a Response inhibition
653		a Rat
653		a Mouse
700	1	a Mar, A. C.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.;NYU, Med Ctr, Dept Neurosci & Physiol, New York, NY 10016 USA.4 aut
700	1	a Nilsson, S. R. O.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.4 aut
700	1	a Alsioe, J.u Uppsala universitet,Institutionen för neurovetenskap4 aut
700	1	a Heath, C. J.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.4 aut
700	1	a Saksida, L. M.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.4 aut
700	1	a Robbins, T. W.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.4 aut
700	1	a Bussey, T. J.u Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.4 aut
710	2	a Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.b Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England.;Univ Cambridge, MRC, Cambridge CB2 3EB, England.;Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England.;NYU, Med Ctr, Dept Neurosci & Physiol, New York, NY 10016 USA.4 org
773	0	t Psychopharmacologyd : Springer Science and Business Media LLCg 232:21-22, s. 3853-3872q 232:21-22<3853-3872x 0033-3158x 1432-2072
856	4	u https://www.repository.cam.ac.uk/bitstream/1810/248850/1/Hvoslef-Eide-et-al%20Journal%20of%20Psychopharmacology%20.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267485
856	4 8	u https://doi.org/10.1007/s00213-015-4007-x

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Av författaren/redakt...: Hvoslef-Eide, M.; Mar, A. C.; Nilsson, S. R. O ...; Alsioe, J.; Heath, C. J.; Saksida, L. M.; visa fler...; Robbins, T. W.; Bussey, T. J.; visa färre...

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