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Sökning: WFRF:(Federici A B) > (2010-2014) > Validation of a rap...

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FältnamnIndikatorerMetadata
00003840naa a2200505 4500
001oai:lup.lub.lu.se:3fc96eae-581d-4993-b2dc-ad9f8f73d70f
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/16721002 URI
0247 a https://doi.org/10.1016/j.thromres.2010.06.0132 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Castaman, G.4 aut
2451 0a Validation of a rapid test (VWF-LIA) for the quantitative determination of von Willebrand factor antigen in type 1 von Willebrand disease diagnosis within the European multicenter study MCMDM-1VWD
264 1b Elsevier BV,c 2010
520 a Background: Accurate measurement of von Willebrand factor (VWF) is a critical requirement for the diagnosis of von Willebrand disease (VWD). Aim of the study: To evaluate the diagnostic efficiency of a rapid quantitative test for the measurement of VWF antigen (VWF:Ag) in type 1 VWD. Patients and methods: VWF: Ag was measured with an ELISA in a robotic instrument, as a reference method, and with a fully automated latex-immunoassay (LIA) on an ACL 9000 analyser in 1,716 subjects enrolled within the Molecular and Clinical Markers for Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD) Study. Among these subjects, 1,049 were healthy controls, 281 healthy family members and 386 affected members from 127 European families with type 1 VWD. Results: The assay linearity range was 10-125 IU/dL for LIA (R-2 = 0.99) and 5-133 IU/dL for ELISA (R-2 = 0.99). The inter-assay CV for low VWF levels (similar to 30 IU/dL) was 2% for the LIA test and 8.7 % for ELISA. The sensitivity for detection of type 1 VWD affected members was 86% and the specificity 91% for LIA, 87% and 90% for ELISA. A receiver-operator (ROC) analysis disclosed only a marginal difference between the two tests, LIA having a slightly greater area under the curve (0.94 vs. 0.93, p = 0.03). Conclusion: VWF: Ag LIA compared well to standard ELISA in this large population of patients and controls, showing better CV. However the lower detection limit for the VWF: Ag LIA compared to the VWF: Ag ELISA means that the LIA assay is less good at discriminating between type 3 VWD and moderate type 1 VWD. (C) 2010 Elsevier Ltd. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a disorders
653 a Inherited bleeding
653 a von Willebrand factor
653 a von Willebrand disease
7001 a Tosetto, A.4 aut
7001 a Cappelletti, A.4 aut
7001 a Goodeve, A.4 aut
7001 a Federici, A. B.4 aut
7001 a Batlle, J.4 aut
7001 a Meyer, D.4 aut
7001 a Goudemand, J.4 aut
7001 a Eikenboom, J. C. J.4 aut
7001 a Schneppenheim, R.4 aut
7001 a Budde, U.4 aut
7001 a Ingerslev, J.4 aut
7001 a Lethagen, Stefanu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-sle
7001 a Hill, F.4 aut
7001 a Peake, I. R.4 aut
7001 a Rodeghiero, F.4 aut
7102 a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org
7730 t Thrombosis Researchd : Elsevier BVg 126:3, s. 227-231q 126:3<227-231x 1879-2472x 0049-3848
8564 u http://dx.doi.org/10.1016/j.thromres.2010.06.013y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1672100
8564 8u https://doi.org/10.1016/j.thromres.2010.06.013

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