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Clinical characteri...
Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer : a Swedish cohort study
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- Ullgren, Helena (författare)
- Umeå universitet,Institutionen för omvårdnad,Regional Cancer Center, Stockholm-Gotland, Sweden; Theme Cancer, Karolinska University Hospital, Stockholm, Sweden,Umeå Univ, Dept Nursing, Umeå, Sweden.;Reg Canc Ctr, Stockholm, Sweden.;Karolinska Univ Hosp, Theme Canc, D1 06, S-17176 Stockholm, Sweden.
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- Camuto, Angela (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Rosas, Sumy (författare)
- Theme Cancer, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Theme Canc, D1 06, S-17176 Stockholm, Sweden.
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- Pahnke, Simon (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Ginman, Beatrice (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Enblad, Gunilla (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi
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- Fransson, Per (författare)
- Umeå universitet,Institutionen för omvårdnad,Umeå Univ, Dept Nursing, Umeå, Sweden.
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- Friesland, Signe (författare)
- Theme Cancer, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Theme Canc, D1 06, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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- Liu, Lisa (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Taylor & Francis Group, 2021
- 2021
- Engelska.
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Ingår i: Acta Oncologica. - : Taylor & Francis Group. - 0284-186X .- 1651-226X. ; 60:11, s. 1459-1465
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Cancer patients are considered to have a higher risk of dying and developing severe Coronavirus Disease 2019 (COVID-19). To date, there are few studies including co-morbidities and sociodemographic factors when investigating the outcome of COVID-19 in a cohort of cancer patients. In this study, we analyzed cancer patients that have been hospitalized due to COVID-19 during the first wave of the pandemic in Sweden to investigate the impact of COVID-19 on mortality and morbidity.Patients and methods: We retrospectively collected data on all patients with cancer that were hospitalized due to COVID-19-related symptoms at Uppsala University Hospital and Karolinska University Hospital between 1 March and 31 August 2020. The primary endpoint was COVID-19-related death and the secondary endpoint was to describe COVID-19 severity, defined as symptom severity (grades 0–4) and length of stay (LOS) at the university hospitals.Results: In total, 193 patients were included among which 31% died due to COVID-19 and 8% died of other causes. In a multivariable analysis, older age >70 (OR 3.6; 95% CI [1.8–7.3], p < 0.001) and male gender (OR 2.8 [1.4–5.8], p = 0.005) were factors associated with higher likelihood of COVID-19-related death. Several comorbidities ≥2 (OR 5.4 [2.0–14.3], p = 0.001) was independently associated with COVID-19 severity. Treatment with chemotherapy within 90 days prior to COVID-19 diagnosis were not associated with COVID-19-related death or severity.Conclusion: Factors associated with higher likelihood of COVID-19-related death were older age and male gender. More severe COVID-19 symptoms were seen in patients with multiple comorbidities. We did not see any associations between COVID-19-related death or severity and recent treatment including chemotherapy. In summary, this supports a thorough assessment regarding potential risks with COVID-19 infection in patients with cancer, with a combination of individual risk factors in addition to cancer treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Cancer
- chemotherapy
- COVID-19
- death
- mortality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Ullgren, Helena
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Camuto, Angela
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Rosas, Sumy
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Pahnke, Simon
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Ginman, Beatrice
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Enblad, Gunilla
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Glimelius, Ingri ...
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Fransson, Per
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Friesland, Signe
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Liu, Lisa
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Acta Oncologica
- Av lärosätet
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet