Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens: a CIBMTR report

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Fältnamn	Indikatorer	Metadata
000		13776naa a2201357 4500
001		oai:DiVA.org:uu-419793
003		SwePub
008		200916s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:144221407
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4197932 URI
024	7	a https://doi.org/10.1182/bloodadvances.20190012662 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442214072 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Zhou, Zhengu Lahey Hosp & Med Ctr, Beth Israel Lahey Hlth, Burlington, MA 01805 USA.4 aut
245	1 0	a Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens :b a CIBMTR report
264		c 2020-07-14
264	1	b American Society of Hematology,c 2020
338		a print2 rdacarrier
520		a There is a lack of large comparative study on the outcomes of reduced intensity conditioning (RIC) in acute myeloid leukemia (AML) transplantation using fludarabine/busulfan (FB) and fludarabine/melphalan (FM) regimens. Adult AML patients from Center for International Blood and Marrow Transplant Research who received first RIC allo-transplant between 2001 and 2015 were studied. Patients were excluded if they received cord blood or identical twin transplant, total body irradiation in conditioning, or graft-versus-host disease (GVHD) prophylaxis with in vitro T-cell depletion. Primary outcome was overall survival (OS), secondary end points were leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and GVHD. Multivariate survival model was used with adjustment for patient, leukemia, and transplant-related factors. A total of 622 patients received FM and 791 received FB RIC. Compared with FB, the FM group had fewer transplant in complete remission (CR), fewer matched sibling donors, and less usage of anti-thymocyte globulin or alemtuzumab. More patients in the FM group received marrow grafts and had transplantation before 2005. OS was significantly lower within the first 3 months posttransplant in the FM group (hazard ratio [HR] = 1.82, P < .001), but was marginally superior beyond 3 months (HR = 0.87, P = .05). LFS was better with FM compared with FB (HR = 0.89, P = .05). NRM was significantly increased in the FM group during the first 3 months of posttransplant (HR = 3.85, P < .001). Long-term relapse was lower with FM (HR = 0.65, P < .001). Analysis restricted to patients with CR showed comparable results. In conclusion, compared with FB, the FM RIC showed a marginally superior long-term OS and LFS and a lower relapse rate. A lower OS early posttransplant within 3 months was largely the result of a higher early NRM.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
700	1	a Nath, Rajneeshu Banner MD Anderson Canc Ctr, Gilbert, AZ USA.4 aut
700	1	a Cerny, Janu Univ Massachusetts, Med Ctr, Dept Med, 3Div Hematol Oncol, Worcester, MA USA.4 aut
700	1	a Wang, Hai-Linu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.4 aut
700	1	a Zhang, Mei-Jieu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut
700	1	a Abdel-Azim, Hishamu Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA.4 aut
700	1	a Agrawal, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.4 aut
700	1	a Ahmed, Gulrayzu Med Coll Wisconsin, Internal Med, Milwaukee, WI 53226 USA.4 aut
700	1	a Al-Homsi, A. Sameru NYU, Langone Med Ctr, New York, NY USA.4 aut
700	1	a Aljurf, Mahmoudu King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.4 aut
700	1	a Alkhateeb, Hassan B.u Mayo Clin, Bone Marrow Transplant Program, Rochester, MN USA.4 aut
700	1	a Assal, Ameru NYPH Columbia Univ Med Ctr, New York, NY USA.4 aut
700	1	a Bacher, Ulrikeu Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland.4 aut
700	1	a Bajel, Ashishu Royal Melbourne Hosp, City Campus, Parkville, Vic, Australia.4 aut
700	1	a Bashir, Qaiseru Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.4 aut
700	1	a Battiwalla, Minocheru Sarah Cannon Blood Canc Network, Nashville, TN USA.4 aut
700	1	a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut
700	1	a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut
700	1	a Cahn, Jean-Yvesu Ctr Hosp Univ Grenoble Alpes, Dept Hematol, Grenoble, France.4 aut
700	1	a Cairo, Mitchellu New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut
700	1	a Choe, Hannahu Ohio Univ, Wexner Med Ctr, James Comprehens Canc Ctr, Columbus, OH USA.4 aut
700	1	a Copelan, Edwardu Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.4 aut
700	1	a Cutler, Coreyu Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.4 aut
700	1	a Damlaj, Moussab B.u King Saud Bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia.4 aut
700	1	a DeFilipp, Zachariahu Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.4 aut
700	1	a De Lima, Marcosu Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.4 aut
700	1	a Diaz, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.4 aut
700	1	a Farhadfar, Noshau Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut
700	1	a Foran, Jamesu Mayo Clin, Bone Marrow Transplant Program, Jacksonville, FL 32224 USA.4 aut
700	1	a Freytes, Cesar O.u Texas Transplant Inst, San Antonio, TX USA.4 aut
700	1	a Gerds, Aaron T.u Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.4 aut
700	1	a Gergis, Usamau New York Presbyterian Hosp, Dept Med Oncol, Hematol Malignancies & Bone Marrow Transplant, Weill Cornell Med Ctr, New York, NY USA.4 aut
700	1	a Grunwald, Michael R.u Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.4 aut
700	1	a Gul, Zartashu Univ Cincinnati, Med Ctr, Cincinnati, OH 45267 USA.4 aut
700	1	a Hamadani, Mehdiu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.4 aut
700	1	a Hashmi, Shahrukhu Mayo Clin, Dept Internal Med, Rochester, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.4 aut
700	1	a Hertzberg, Marku Prince Wales Hosp, Dept Haematol, Randwick, NSW, Australia.4 aut
700	1	a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut
700	1	a Hossain, Nasheedu Loyola Univ Chicago, Stritch Sch Med, Dept Med, Stem Cell Transplant Program,Div Hematol Oncol, Maywood, IL USA.4 aut
700	1	a Inamoto, Yoshihirou Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.4 aut
700	1	a Isola, Luisu Mt Sinai Med Ctr, New York, NY 10029 USA.4 aut
700	1	a Jain, Taniau Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.4 aut
700	1	a Kamble, Rammurti T.u Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA.4 aut
700	1	a Khan, Muhammad Waqasu Louisiana State Univ, Bone Marrow Transplant Program, Div Hematol Oncol, Baton Rouge, LA 70803 USA.4 aut
700	1	a Kharfan-Dabaja, Mohamed A.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut
700	1	a Kebriaei, Partowu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.4 aut
700	1	a Kekre, Natashau Ottawa Hosp Blood & Marrow Transplant Program, Ottawa, ON, Canada.4 aut
700	1	a Khera, Nanditau Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA.4 aut
700	1	a Lazarus, Hillard M.u Case Western Reserve Univ, Cleveland, OH 44106 USA.4 aut
700	1	a Liesveld, Jane L.u Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.4 aut
700	1	a Litzow, Marku Mayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA.4 aut
700	1	a Liu, Hongtaou Univ Chicago Med, Chicago, IL USA.4 aut
700	1	a Marks, David, Iu Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.4 aut
700	1	a Martino, Rodrigou Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain.4 aut
700	1	a Mathews, Vikramu Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.4 aut
700	1	a Mishra, Asmitau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut
700	1	a Murthy, Hemant S.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut
700	1	a Nagler, Arnonu Chaim Sheba Med Ctr, Hematol Div, Tel Hashomer, Israel.;Chaim Sheba Med Ctr, BMT, Tel Hashomer, Israel.;Tel Aviv Univ, Div Hematol & Bone Marrow Transplantat, Tel Aviv, Israel.;Tel Aviv Univ, Cord Blood Bank, Tel Aviv, Israel.4 aut
700	1	a Nakamura, Ryotarou City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.4 aut
700	1	a Nathan, Sunitau Rush Univ, Med Ctr, Chicago, IL 60612 USA.4 aut
700	1	a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut
700	1	a Olin, Rebeccau Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut
700	1	a Olsson, Richard F.u Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.4 aut0 (Swepub:uu)riols677
700	1	a Palmisiano, Neilu Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA.4 aut
700	1	a Patel, Sagar S.u Univ Utah, Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut
700	1	a Patnaik, Mrinal M.u Mayo Clin, Bone Marrow Transplant Program, Rochester, MN USA.4 aut
700	1	a Pawarode, Attapholu Univ Michigan, Sch Med, Dept Internal Med, Div Hematol Oncol,Blood & Marrow Transplantat Pro, Ann Arbor, MI USA.4 aut
700	1	a Perales, Miguel-Angelu Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA.4 aut
700	1	a Politikos, Ioannisu Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA.4 aut
700	1	a Popat, Udayu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.4 aut
700	1	a Rizzieri, Davidu Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.4 aut
700	1	a Sandmaier, Brenda M.u Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut
700	1	a Seo, Sachikou Dokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan.4 aut
700	1	a Shah, Nirav N.u Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA.4 aut
700	1	a Uy, Geoffrey L.u Washington Univ, Sch Med, Div Oncol, St Louis, MO USA.4 aut
700	1	a Valcarcel, Davidu Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain.4 aut
700	1	a Verdonck, Leo F.u Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.4 aut
700	1	a Waller, Edmund K.u Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.4 aut
700	1	a Wang, Youjinu NCI, NIH, Rockville, MD USA.4 aut
700	1	a Weisdorf, Danielu Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut
700	1	a Wirk, Baldeepu Penn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA.4 aut
700	1	a Wong, Ericu Royal Melbourne Hosp, City Campus, Parkville, Vic, Australia.4 aut
700	1	a Yared, Jean A.u Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.4 aut
700	1	a Saber, Waelu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.4 aut
710	2	a Lahey Hosp & Med Ctr, Beth Israel Lahey Hlth, Burlington, MA 01805 USA.b Banner MD Anderson Canc Ctr, Gilbert, AZ USA.4 org
773	0	t Blood Advancesd : American Society of Hematologyg 4:13, s. 3180-3190q 4:13<3180-3190x 2473-9529x 2473-9537
856	4	u https://ashpublications.org/bloodadvances/article/4/13/3180/461319/Reduced-intensity-conditioning-for-acute-myeloid
856	4	u https://ashpublications.org/bloodadvances/article-pdf/4/13/3180/1810861/advancesadv2019001266.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419793
856	4 8	u https://doi.org/10.1182/bloodadvances.2019001266
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:144221407

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