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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006329naa a2200553 4500
001oai:DiVA.org:hh-45993
003SwePub
008211209s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-459932 URI
0247 a https://doi.org/10.1016/j.jsams.2021.08.0092 DOI
040 a (SwePub)hh
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Garthwaite, Taruu Turku University Hospital, Turku, Finland4 aut
2451 0a Standing is associated with insulin sensitivity in adults with metabolic syndrome
264 1a Chatswood :b Elsevier,c 2021
338 a print2 rdacarrier
500 a This work was supported by Academy of Finland; Finnish Cultural Foundation; Finnish Diabetes Research Foundation; Hospital District of Southwest Finland; and Juho Vainio Foundation. The study funders were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.The authors regret an error in the fourth paragraph of the Methods section. This should read as follows:Whole-body insulin-stimulated glucose uptake (M-value) was measured with a hyperinsulinaemic–euglycaemic clamp after fasting overnight. Insulin (Actrapid, 100 U/ml, Novo Nordisk, Bagsvaerd, Denmark) was infused at a 160 mU/m2/min body surface area/min rate during the first 4 min, at 80 mU/m2/min during minutes 4–7, and thereafter at 40 mU/m2/min. Four minutes after starting insulin infusion, 20% glucose infusion was started. The rate was adjusted according to plasma glucose concentration measured every 5–10 min. M-value (μmol/kg/min) was calculated in 20-min intervals from steady-state glucose values. Fasting insulin and HOMA-IR were determined as surrogate markers of insulin sensitivity as described below. The authors regret any inconvenience caused. © 2022 The Author(s). Published by Elsevier Ltd on behalf of Sports Medicine Australia.
520 a Objectives: To determine how components of accelerometer-measured sedentary behavior (SB) and physical activity (PA), and fitness are associated with insulin sensitivity in adults with metabolic syndrome. Design: Cross-sectional. Methods: Target population was middle-aged (40–65 years) sedentary adults with metabolic syndrome. SB, breaks in SB, standing, and PA were measured for four weeks with hip-worn accelerometers. VO2max (ml/min/kg) was measured with maximal cycle ergometry. Insulin sensitivity was determined by hyperinsulinaemic-euglycaemic clamp (M-value) and fasting blood sampling (HOMA-IR, insulin). Multivariable regression was used for analyses. Results: Sixty-four participants (37 women; 58.3 [SD 6.8] years) were included. Participants spent 10.0 (1.0) h sedentary, 1.8 (0.6) h standing, and 2.7 (0.6) h in PA and took 5149 (1825) steps and 29 (8) breaks daily. In sex-, age- and accelerometer wear time-adjusted model SB, standing, steps and VO2max were associated with M-value (β = −0.384; β = 0.400; β = 0.350; β = 0.609, respectively), HOMA-IR (β = 0.420; β = −0.548; β = −0.252; β = −0.449), and insulin (β = 0.433; β = −0.541; β = −0.252; β = −0.453); all p-values < 0.05. Breaks associated only with M-value (β = 0.277). When further adjusted for body fat %, only standing remained significantly associated with HOMA-IR (β = −0.381) and insulin (β = −0.366); significance was maintained even when further adjusted for SB, PA and fitness. Light and moderate-to-vigorous PA were not associated with insulin sensitivity. Conclusions: Standing is associated with insulin sensitivity markers. The association with HOMA-IR and insulin is independent of adiposity, PA, SB and fitness. Further studies are warranted, but these findings encourage replacing sitting with standing for potential improvements in insulin sensitivity in adults at increased type 2 diabetes risk. © 2021 The Authors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Cardiorespiratory fitness
653 a Insulin resistance
653 a Metabolic syndrome
653 a Physical activity
653 a Sedentary behavior
7001 a Sjöros, Tanjau Turku University Hospital, Turku, Finland4 aut
7001 a Koivumäki, Mikkou Turku University Hospital, Turku, Finland4 aut
7001 a Laine, Saarau Turku University Hospital, Turku, Finland4 aut
7001 a Vähä-Ypyä, Henriu UKK Institute Finland, Tampere, Finland4 aut
7001 a Saarenhovi, Mariau Turku University Hospital, Turku, Finland4 aut
7001 a Kallio, Petriu Turku University Hospital, Turku, Finland; University of Turku, Turku, Finland4 aut
7001 a Löyttyniemi, Eliisau University of Turku, Turku, Finland4 aut
7001 a Sievänen, Harriu UKK Institute Finland, Tampere, Finland4 aut
7001 a Houttu, Noorau University of Turku, Turku, Finland4 aut
7001 a Laitinen, Kirsiu University of Turku, Turku, Finland4 aut
7001 a Kalliokoski, Kariu Turku University Hospital, Turku, Finland4 aut
7001 a Vasankari, Tommiu UKK Institute Finland, Tampere, Finland; Tampere University, Tampere, Finland4 aut
7001 a Knuuti, Juhaniu Turku University Hospital, Turku, Finland4 aut
7001 a Heinonen, Ilkka,d 1982-u Högskolan i Halmstad,Rydberglaboratoriet för tillämpad naturvetenskap (RLAS),Turku University Hospital, Turku, Finland4 aut0 (Swepub:hh)ilkhei
7102 a Turku University Hospital, Turku, Finlandb UKK Institute Finland, Tampere, Finland4 org
7730 t Journal of Science and Medicine in Sportd Chatswood : Elsevierg 24:12, s. 1255-1260q 24:12<1255-1260x 1440-2440x 1878-1861
8564 u https://doi.org/10.1016/j.jsams.2021.08.009y Fulltext
8564 u https://doi.org/10.1016/j.jsams.2022.03.002y Corrigendum
8564 u http://www.jsams.org/article/S1440244021002048/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-45993
8564 8u https://doi.org/10.1016/j.jsams.2021.08.009

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