Search: WFRF:(Liu YJ) > Multi-ancestry stud...
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003 | SwePub | |
008 | 240701s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-156317 | |
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024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1400708642 URI |
024 | 7 | a https://doi.org/10.1038/s41467-018-08008-w2 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1563172 URI |
024 | 7 | a https://lup.lub.lu.se/record/ddccdd28-505a-425f-bbb9-5250d5206f472 URI |
040 | a (SwePub)kid (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
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100 | 1 | a Kilpelainen, TOu University of Copenhagen,Icahn School of Medicine at Mount Sinai4 aut |
245 | 1 0 | a Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
264 | c 2019-01-22 | |
264 | 1 | a London :b Springer Science and Business Media LLC,c 2019 |
520 | a Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
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700 | 1 | a Winkler, TW4 aut |
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700 | 1 | a Ntalla, I4 aut |
700 | 1 | a Aschard, H4 aut |
700 | 1 | a Brown, MR4 aut |
700 | 1 | a de las Fuentes, Lu Karolinska Institutet4 aut |
700 | 1 | a Franceschini, N4 aut |
700 | 1 | a Guo, XQ4 aut |
700 | 1 | a Vojinovic, D4 aut |
700 | 1 | a Aslibekyan, S4 aut |
700 | 1 | a Feitosa, MF4 aut |
700 | 1 | a Kho, Mu Karolinska Institutet4 aut |
700 | 1 | a Musani, SK4 aut |
700 | 1 | a Richard, M4 aut |
700 | 1 | a Wang, HM4 aut |
700 | 1 | a Wang, Z4 aut |
700 | 1 | a Bartz, TM4 aut |
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700 | 1 | a Campbell, A4 aut |
700 | 1 | a Dorajoo, R4 aut |
700 | 1 | a Fisher, V4 aut |
700 | 1 | a Franks, Paulu Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University4 aut0 (Swepub:lu)med-plf |
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700 | 1 | a Boissel, M4 aut |
700 | 1 | a Chai, JF4 aut |
700 | 1 | a Chen, Xu Karolinska Institutet4 aut |
700 | 1 | a Divers, J4 aut |
700 | 1 | a Evangelou, E4 aut |
700 | 1 | a Gao, Cu Washington University in St. Louis4 aut |
700 | 1 | a Graff, M4 aut |
700 | 1 | a Harris, SE4 aut |
700 | 1 | a He, MA4 aut |
700 | 1 | a Hsu, FC4 aut |
700 | 1 | a Jackson, AU4 aut |
700 | 1 | a Zhao, JH4 aut |
700 | 1 | a Kraja, AT4 aut |
700 | 1 | a Kuhnel, B4 aut |
700 | 1 | a Laguzzi, Fu Karolinska Institutet4 aut |
700 | 1 | a Lyytikainen, LPu Karolinska Institutet4 aut |
700 | 1 | a Nolte, IM4 aut |
700 | 1 | a Rauramaa, R4 aut |
700 | 1 | a Riaz, M4 aut |
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700 | 1 | a van der Most, PJ4 aut |
700 | 1 | a V. Varga, Tiboru Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-tv_ |
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700 | 1 | a Wennberg, Patrik,d 1972-u Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)pawe0002 |
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700 | 1 | a Langefeld, CD4 aut |
700 | 1 | a Langenberg, C4 aut |
700 | 1 | a Launer, LJ4 aut |
700 | 1 | a Leander, Ku Karolinska Institutet4 aut |
700 | 1 | a Lemaitre, RN4 aut |
700 | 1 | a Lewis, CE4 aut |
700 | 1 | a Liang, JJ4 aut |
700 | 1 | a Alizadeh, BZ4 aut |
700 | 1 | a Boezen, HM4 aut |
700 | 1 | a Franke, Lu Icahn School of Medicine at Mount Sinai4 aut |
700 | 1 | a Navis, G4 aut |
700 | 1 | a Rots, M4 aut |
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700 | 1 | a Wolffenbuttel, BHR4 aut |
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700 | 1 | a Papanicolau, GJ4 aut |
700 | 1 | a Pazoki, R4 aut |
700 | 1 | a Pedersen, NLu Karolinska Institutet4 aut |
700 | 1 | a Peters, A4 aut |
700 | 1 | a Poveda, Alaitzu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-azp |
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700 | 1 | a van Heemst, D4 aut |
700 | 1 | a Voortman, T4 aut |
700 | 1 | a Waldenberger, M4 aut |
700 | 1 | a Franks, Paul W.u Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, USA; OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK4 aut0 (Swepub:umu)pafr0003 |
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700 | 1 | a de Faire, Uu Karolinska Institutet4 aut |
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700 | 1 | a Elliott, P4 aut |
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700 | 1 | a Lakka, TA4 aut |
700 | 1 | a Lehtimaki, T4 aut |
700 | 1 | a Magnusson, PKEu Karolinska Institutet4 aut |
700 | 1 | a Oldehinkel, AJ4 aut |
700 | 1 | a Penninx, BWJH4 aut |
700 | 1 | a Samani, NJ4 aut |
700 | 1 | a Shu, XO4 aut |
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710 | 2 | a University of Copenhagenb Icahn School of Medicine at Mount Sinai4 org |
710 | 2 | a et al. |
773 | 0 | t Nature communicationsd London : Springer Science and Business Media LLCg 10:1, s. 376-q 10:1<376-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-018-08008-w.pdf |
856 | 4 | u https://doi.org/10.1038/s41467-018-08008-wy Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1290381/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1038/s41467-018-08008-wx freey FULLTEXT |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140070864 |
856 | 4 8 | u https://doi.org/10.1038/s41467-018-08008-w |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156317 |
856 | 4 8 | u https://lup.lub.lu.se/record/ddccdd28-505a-425f-bbb9-5250d5206f47 |
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