Sökning: WFRF:(Nagy Edit) > Subclinical atheros...
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000 | 05250naa a2200577 4500 | |
001 | oai:lup.lub.lu.se:8308e68a-d8a1-4b37-8838-bb18e83a0cb3 | |
003 | SwePub | |
008 | 181113s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140045723 | |
009 | oai:gup.ub.gu.se/273776 | |
024 | 7 | a https://lup.lub.lu.se/record/8308e68a-d8a1-4b37-8838-bb18e83a0cb32 URI |
024 | 7 | a https://doi.org/10.1016/j.ijcard.2018.08.1042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1400457232 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2737762 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Tarp, Julie Bjerreu University of Copenhagen4 aut |
245 | 1 0 | a Subclinical atherosclerosis in patients with cyanotic congenital heart disease |
264 | 1 | b Elsevier BV,c 2019 |
520 | a Introduction: Survival in patients with cyanotic congenital heart disease (CCHD) has improved dramatically. The result is an ageing population with risk of acquired heart disease. Previous small uncontrolled studies suggested that these patients are protected against the development of atherosclerosis. To test this hypothesis, we sought to determine the prevalence of subclinical atherosclerosis in a larger population of patients with CCHD. Method: We compared the prevalence of subclinical atherosclerosis in adult CCHD patients from Denmark, Sweden, Norway and Australia, with that in age-, sex-, smoking status-, and body mass index matched controls. Coronary artery atherosclerosis was assessed on computed tomography with coronary artery calcification (CAC) score. Subclinical atherosclerosis was defined by CAC-score > 0. Carotid artery atherosclerosis was evaluated using ultrasound by measuring carotid plaque thickness (cPT-max) and carotid intima media thickness (CIMT). Lipid status was evaluated as an important atherosclerotic risk factor. Results: Seventy-four patients with CCHD (57% women, median age 49.5 years) and 74 matched controls (57% women, median age 50.0 years) were included. There were no differences between the groups in: CAC-score > 0 (21% vs. 19%, respectively; p = 0.8), carotid plaques (19% vs. 9%, respectively; p = 0.1), cPT-max (2.3 mm vs. 2.8 mm, respectively; p = 0.1) or CIMT (0.61 mm vs. 0.61 mm, respectively; p = 0.98). And further no significant differences in lipoprotein concentrations measured by ultracentrifugation. Conclusion: Young adults with CCHD have similar cardiovascular risk factor profiles and measures of subclinical atherosclerosis, compared with controls. Given their increasing life expectancies, athero-preventive strategies should be an important part of their clinical management. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a Cardiovascular disease | |
653 | a Carotid artery atherosclerosis | |
653 | a Coronary artery atherosclerosis | |
653 | a Coronary artery calcification | |
653 | a Cyanotic congenital heart disease | |
653 | a Hyperlipidemia | |
700 | 1 | a Sørgaard, Mathias Holmu University of Copenhagen4 aut |
700 | 1 | a Christoffersen, Christinau University of Copenhagen,Copenhagen University Hospital4 aut |
700 | 1 | a Jensen, Annette Schophuusu University of Copenhagen4 aut |
700 | 1 | a Sillesen, Henriku University of Copenhagen4 aut |
700 | 1 | a Celermajer, Davidu Royal Prince Alfred Hospital4 aut |
700 | 1 | a Eriksson, Peter J,d 1959u Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xerpet |
700 | 1 | a Estensen, Mette Eliseu Norwegian Radium Hospital4 aut |
700 | 1 | a Nagy, Editu Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Holstein-Rathlou, Niels Henriku University of Copenhagen4 aut |
700 | 1 | a Engstrøm, Thomasu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Copenhagen4 aut0 (Swepub:lu)th4331en |
700 | 1 | a Søndergaard, Larsu University of Copenhagen4 aut |
710 | 2 | a University of Copenhagenb Copenhagen University Hospital4 org |
773 | 0 | t International Journal of Cardiologyd : Elsevier BVg 277, s. 97-103q 277<97-103x 0167-5273x 1874-1754 |
856 | 4 | u http://dx.doi.org/10.1016/j.ijcard.2018.08.104y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/8308e68a-d8a1-4b37-8838-bb18e83a0cb3 |
856 | 4 8 | u https://doi.org/10.1016/j.ijcard.2018.08.104 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140045723 |
856 | 4 8 | u https://gup.ub.gu.se/publication/273776 |
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