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Tumor necrosis fact...
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Ternström, Lisa,1972Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
(författare)
Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy
- Artikel/kapitelEngelska2005
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Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/49287
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https://gup.ub.gu.se/publication/49287URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Cardiac allograft vasculopathy (CAV) limits survival after cardiac transplantation. Tumor necrosis factor-alpha (TNF-alpha) may be a key factor in the development of CAV. Two bi-allelic polymorphisms associated with high TNF-alpha production have been identified in the TNF gene locus, TNFA1/2, at position -308 and TNFB1/2 at +252. We hypothesized that recipient TNFA2 and TNFB2 homozygosity is associated with the development of CAV after heart transplantation. METHODS: TNF gene polymorphisms were analyzed by multiplex fluorescent solid-phase mini-sequencing in 70 cardiac transplant recipients. Recipients homozygous for TNFA2 or TNFB2 (Group A, n = 29) were compared with recipients heterozygous or homozygous for TNFA1 and TNFB1 (Group B, n = 41). Coronary arteriography was performed annually or when indicated. Cumulative freedom from CAV and survival was calculated according to the Kaplan-Meier test. RESULTS: Mean follow-up was 3.8 +/- 0.3 years. In Group A, 11 of 29 recipients (38%) developed CAV compared with 9 of 41 (22%) in Group B (p = 0.12). Cumulative freedom from CAV at 3 years was 42% in Group A and 80% in Group B (p = 0.043). In Group A, 11 of 29 recipients (38%) died during follow-up compared with 4 of 41 (10%) in Group B (p = 0.006). Cumulative survival at 3 years was 72% in Group A and 93% in Group B (p = 0.003). CONCLUSIONS: The results suggest that TNFA2 and TNFB2 allele homozygosity is associated with cardiac allograft vasculopathy and mortality in heart transplant recipients.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
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Adult
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Coronary Angiography
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Coronary Arteriosclerosis/*blood/etiology/radiography
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Coronary Vessels/*pathology
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Female
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Follow-Up Studies
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Gene Frequency
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Genetic Markers
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Graft Rejection/blood/prevention & control
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Graft Survival/genetics
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Heart Transplantation/*adverse effects/mortality
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Humans
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Immunosuppressive Agents/therapeutic use
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Male
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Middle Aged
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Polymerase Chain Reaction
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*Polymorphism
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Genetic
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Prospective Studies
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Survival Rate
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Transplantation
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Homologous
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Tumor Necrosis Factor-alpha/biosynthesis/*genetics
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xjepan
(författare)
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Ricksten, Anne,1957Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xrican
(författare)
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Nilsson, Folke,1950Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xnilfo
(författare)
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Göteborgs universitetHjärt-kärlinstitutionen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:J Heart Lung Transplant24:4, s. 433-81053-2498
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