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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009324naa a2200829 4500
001oai:DiVA.org:uu-492256
003SwePub
008230104s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:151401947
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4922562 URI
0247 a https://doi.org/10.7554/eLife.785502 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1514019472 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Vazquez, Sara E.u Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94118 USA.4 aut
2451 0a Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
264 1b eLife Sciences Publications Ltd,c 2022
338 a electronic2 rdacarrier
520 a Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several successful implementations of PhIP-seq for autoantigen discovery, including our previous work (Vazquez et al., 2020), current protocols are inherently difficult to scale to accommodate large cohorts of cases and importantly, healthy controls. Here, we develop and validate a high throughput extension of PhIP-seq in various etiologies of autoimmune and inflammatory diseases, including APS1, IPEX, RAG1/2 deficiency, Kawasaki disease (KD), multisystem inflammatory syndrome in children (MIS-C), and finally, mild and severe forms of COVID-19. We demonstrate that these scaled datasets enable machine-learning approaches that result in robust prediction of disease status, as well as the ability to detect both known and novel autoantigens, such as prodynorphin (PDYN) in APS1 patients, and intestinally expressed proteins BEST4 and BTNL8 in IPEX patients. Remarkably, BEST4 antibodies were also found in two patients with RAG1/2 deficiency, one of whom had very early onset IBD. Scaled PhIP-seq examination of both MIS-C and KD demonstrated rare, overlapping antigens, including CGNL1, as well as several strongly enriched putative pneumonia-associated antigens in severe COVID-19, including the endosomal protein EEA1. Together, scaled PhIP-seq provides a valuable tool for broadly assessing both rare and common autoantigen overlap between autoimmune diseases of varying origins and etiologies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a PhIP-seq
653 a autoantibody
653 a autoantigen
653 a COVID-19
653 a APS1
653 a IPEX
653 a Human
7001 a Mann, Sabrina A.u Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94118 USA.4 aut
7001 a Bodansky, Aaronu Univ Calif San Francisco, Dept Pediat Crit Care Med, San Francisco, CA USA.4 aut
7001 a Kung, Andrew F.u Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.4 aut
7001 a Quandt, Zoeu Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94118 USA.;Univ Calif San Francisco, Dept Med, San Francisco, CA USA.4 aut
7001 a Ferre, Elise M. N.u Natl Inst Allergy & Infect Dis, NIH, Lab Clin Immunol & Microbiol, Fungal Pathogenesis Unit, Bethesda, MD USA.4 aut
7001 a Landegren, Nils,d 1986-u Karolinska Institutet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden.4 aut0 (Swepub:uu)nillan544
7001 a Eriksson, Danielu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden.4 aut0 (Swepub:uu)daner854
7001 a Bastard, Paulu Rockefeller Univ, St Giles Lab Human Genet Infect Dis, New York, NY USA.;Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, Paris, France.;Univ Paris, Imagine Inst, Paris, France.;Necker Hosp Sick Children, Dept Pediat, Paris, France.4 aut
7001 a Zhang, Shen-Yingu Rockefeller Univ, St Giles Lab Human Genet Infect Dis, New York, NY USA.;Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, Paris, France.;Univ Paris, Imagine Inst, Paris, France.4 aut
7001 a Liu, Jaminu Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Univ Calif San Francisco, Berkeley Univ Calif, San Francisco Grad Program Bioengn, San Francisco, CA USA.4 aut
7001 a Mitchell, Antheau Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94118 USA.4 aut
7001 a Proekt, Irinau Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94118 USA.4 aut
7001 a Yu, Davidu Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94118 USA.4 aut
7001 a Mandel-Brehm, Caleighu Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.4 aut
7001 a Wang, Chung-Yuu Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94118 USA.4 aut
7001 a Miao, Brendau Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.4 aut
7001 a Sowa, Gavinu Univ Calif San Francisco, Sch Med, San Francisco, CA USA.4 aut
7001 a Zorn, Kelseyu Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.4 aut
7001 a Chan, Alice Y.u Univ Calif San Francisco, Dept Pediat, Div Pediat Allergy Immunol Bone & Marrow Transplan, Div Pediat Rheumatol, San Francisco, CA USA.4 aut
7001 a Tagi, Veronica M.u Stanford Univ, Div Stem Cell Transplantat & Regenerat Med, Sch Med, Stanford, CA USA.4 aut
7001 a Shimizu, Chisatou Univ Calif San Diego, Rady Childrens Hosp, Kawasaki Dis Res Ctr, La Jolla, CA USA.;Univ Calif San Diego, Dept Pediat, La Jolla, CA USA.4 aut
7001 a Tremoulet, Adrianau Univ Calif San Diego, Rady Childrens Hosp, Kawasaki Dis Res Ctr, La Jolla, CA USA.;Univ Calif San Diego, Dept Pediat, La Jolla, CA USA.4 aut
7001 a Lynch, Karau Univ Calif San Francisco, Dept Lab Med, San Francisco, CA USA.;Zuckerberg San Francisco Gen, San Francisco, CA USA.4 aut
7001 a Wilson, Michael R.u Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA USA.4 aut
7001 a Kaempe, Olleu Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden.;Univ Bergen, Dept Clin Sci, Bergen, Norway.;Univ Bergen, KG Jebsen Ctr Autoimmune Disorders, Bergen, Norway.;Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.4 aut
7001 a Dobbs, Kerryu NIAID, Lab Clin Immunol & Microbiol, NIH, Bethesda, MD USA.4 aut
7001 a Delmonte, Ottavia M.u NIAID, Lab Clin Immunol & Microbiol, NIH, Bethesda, MD USA.4 aut
7001 a Bacchetta, Rosa4 aut
7001 a Notarangelo, Luigi D.u NIAID, Lab Clin Immunol & Microbiol, NIH, Bethesda, MD USA.4 aut
7001 a Burns, Jane C.4 aut
7001 a Casanova, Jean-Laurentu Rockefeller Univ, St Giles Lab Human Genet Infect Dis, New York, NY USA.;Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, Paris, France.;Univ Paris, Imagine Inst, Paris, France.;Necker Hosp Sick Children, Dept Pediat, Paris, France.;Howard Hughes Med Inst, New York, NY USA.4 aut
7001 a Lionakis, Michail S.u Natl Inst Allergy & Infect Dis, NIH, Lab Clin Immunol & Microbiol, Fungal Pathogenesis Unit, Bethesda, MD USA.4 aut
7001 a Torgerson, Troy R.u Seattle Childrens Res Inst, Seattle, WA USA.;Univ Washington, Dept Pediat, Seattle, WA USA.4 aut
7001 a Anderson, Mark S.u Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94118 USA.4 aut
7001 a DeRisi, Joseph L.u Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94118 USA.4 aut
7102 a Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94118 USA.b Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94118 USA.4 org
7730 t eLIFEd : eLife Sciences Publications Ltdg 11q 11x 2050-084X
8564 u https://uu.diva-portal.org/smash/get/diva2:1723783/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-492256
8564 8u https://doi.org/10.7554/eLife.78550
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:151401947

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