An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.

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Fältnamn	Indikatorer	Metadata
000		05748naa a2201057 4500
001		oai:DiVA.org:umu-80870
003		SwePub
008		130927s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-808702 URI
024	7	a https://doi.org/10.1371/journal.pone.00723112 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Klein, Alison P.4 aut
245	1 0	a An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
264		c 2013-09-13
264	1	b Public Library of Science,c 2013
338		a electronic2 rdacarrier
520		a PURPOSE: We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer.PATIENTS AND METHODS: Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates.RESULTS: Our risk model included current smoking (multivariable adjusted odds ratio (OR) and 95% confidence interval: 2.20 [1.84-2.62]), heavy alcohol use (>3 drinks/day) (OR: 1.45 [1.19-1.76]), obesity (body mass index >30 kg/m(2)) (OR: 1.26 [1.09-1.45]), diabetes >3 years (nested case-control OR: 1.57 [1.13-2.18], case-control OR: 1.80 [1.40-2.32]), family history of pancreatic cancer (OR: 1.60 [1.20-2.12]), non-O ABO genotype (AO vs. OO genotype) (OR: 1.23 [1.10-1.37]) to (BB vs. OO genotype) (OR 1.58 [0.97-2.59]), rs3790844(chr1q32.1) (OR: 1.29 [1.19-1.40]), rs401681(5p15.33) (OR: 1.18 [1.10-1.26]) and rs9543325(13q22.1) (OR: 1.27 [1.18-1.36]). The areas under the ROC curve for risk models including only non-genetic factors, only genetic factors, and both non-genetic and genetic factors were 58%, 57% and 61%, respectively. We estimate that fewer than 3/1,000 U.S. non-Hispanic whites have more than a 5% predicted lifetime absolute risk.CONCLUSION: Although absolute risk modeling using established risk factors may help to identify a group of individuals at higher than average risk of pancreatic cancer, the immediate clinical utility of our model is limited. However, a risk model can increase awareness of the various risk factors for pancreatic cancer, including modifiable behaviors.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Lindström, Sara4 aut
700	1	a Mendelsohn, Julie B.4 aut
700	1	a Steplowski, Emily4 aut
700	1	a Arslan, Alan A.4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Fuchs, Charles S.4 aut
700	1	a Gallinger, Steven4 aut
700	1	a Gross, Myron4 aut
700	1	a Helzlsouer, Kathy4 aut
700	1	a Holly, Elizabeth A.4 aut
700	1	a Jacobs, Eric J.4 aut
700	1	a Lacroix, Andrea4 aut
700	1	a Li, Donghui4 aut
700	1	a Mandelson, Margaret T.4 aut
700	1	a Olson, Sara H.4 aut
700	1	a Petersen, Gloria M.4 aut
700	1	a Risch, Harvey A.4 aut
700	1	a Stolzenberg-Solomon, Rachael Z.4 aut
700	1	a Zheng, Wei4 aut
700	1	a Amundadottir, Laufey4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Allen, Naomi E.4 aut
700	1	a Bamlet, William R.4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Buring, Julie E.4 aut
700	1	a Bracci, Paige M.4 aut
700	1	a Canzian, Federico4 aut
700	1	a Clipp, Sandra4 aut
700	1	a Cotterchio, Michelle4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Elena, Joanne4 aut
700	1	a Gaziano, J. Michael4 aut
700	1	a Giovannucci, Edward L.4 aut
700	1	a Goggins, Michael4 aut
700	1	a Hallmans, Göranu Umeå universitet,Enheten för biobanksforskning,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Hassan, Manal4 aut
700	1	a Hutchinson, Amy4 aut
700	1	a Hunter, David J.4 aut
700	1	a Kooperberg, Charles4 aut
700	1	a Kurtz, Robert C.4 aut
700	1	a Liu, Simin4 aut
700	1	a Overvad, Kim4 aut
700	1	a Palli, Domenico4 aut
700	1	a Patel, Alpa V.4 aut
700	1	a Rabe, Kari G.4 aut
700	1	a Shu, Xiao-Ou4 aut
700	1	a Slimani, Nadia4 aut
700	1	a Tobias, Geoffrey S.4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Van Den Eeden, Stephen K.4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Wactawski-Wende, Jean4 aut
700	1	a Wolpin, Brian M.4 aut
700	1	a Yu, Herbert4 aut
700	1	a Yu, Kai4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Kraft, Peter4 aut
710	2	a Umeå universitetb Enheten för biobanksforskning4 org
773	0	t PLOS ONEd : Public Library of Scienceg 8:9q 8:9x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0072311y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:651757/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072311&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80870
856	4 8	u https://doi.org/10.1371/journal.pone.0072311

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Av författaren/redakt...: Klein, Alison P.; Lindström, Sara; Mendelsohn, Juli ...; Steplowski, Emil ...; Arslan, Alan A.; Bueno-de-Mesquit ...; visa fler...; Fuchs, Charles S ...; Gallinger, Steve ...; Gross, Myron; Helzlsouer, Kath ...; Holly, Elizabeth ...; Jacobs, Eric J.; Lacroix, Andrea; Li, Donghui; Mandelson, Marga ...; Olson, Sara H.; Petersen, Gloria ...; Risch, Harvey A.; Stolzenberg-Solo ...; Zheng, Wei; Amundadottir, La ...; Albanes, Demetri ...; Allen, Naomi E.; Bamlet, William ...; Boutron-Ruault, ...; Buring, Julie E.; Bracci, Paige M.; Canzian, Federic ...; Clipp, Sandra; Cotterchio, Mich ...; Duell, Eric J.; Elena, Joanne; Gaziano, J. Mich ...; Giovannucci, Edw ...; Goggins, Michael; Hallmans, Göran; Hassan, Manal; Hutchinson, Amy; Hunter, David J.; Kooperberg, Char ...; Kurtz, Robert C.; Liu, Simin; Overvad, Kim; Palli, Domenico; Patel, Alpa V.; Rabe, Kari G.; Shu, Xiao-Ou; Slimani, Nadia; Tobias, Geoffrey ...; Trichopoulos, Di ...; Van Den Eeden, S ...; Vineis, Paolo; Virtamo, Jarmo; Wactawski-Wende, ...; Wolpin, Brian M.; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquo ...; Chanock, Stephen ...; Hoover, Robert N ...; Hartge, Patricia; Kraft, Peter; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Umeå universitet

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