Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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Fältnamn	Indikatorer	Metadata
000		09200naa a2202329 4500
001		oai:lup.lub.lu.se:7553dae4-0464-42ca-8c45-78d32d2b97af
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:122295667
024	7	a https://lup.lub.lu.se/record/19250302 URI
024	7	a https://doi.org/10.1038/ng.7842 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1222956672 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Schunkert, Heribert4 aut
245	1 0	a Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
264		c 2011-03-06
264	1	b Springer Science and Business Media LLC,c 2011
520		a We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Koenig, Inke R.4 aut
700	1	a Kathiresan, Sekar4 aut
700	1	a Reilly, Muredach P.4 aut
700	1	a Assimes, Themistocles L.4 aut
700	1	a Holm, Hilma4 aut
700	1	a Preuss, Michael4 aut
700	1	a Stewart, Alexandre F. R.4 aut
700	1	a Barbalic, Maja4 aut
700	1	a Gieger, Christian4 aut
700	1	a Absher, Devin4 aut
700	1	a Aherrahrou, Zouhair4 aut
700	1	a Allayee, Hooman4 aut
700	1	a Altshuler, David4 aut
700	1	a Anand, Sonia S.4 aut
700	1	a Andersen, Karl4 aut
700	1	a Anderson, Jeffrey L.4 aut
700	1	a Ardissino, Diego4 aut
700	1	a Ball, Stephen G.u Karolinska Institutet4 aut
700	1	a Balmforth, Anthony J.4 aut
700	1	a Barnes, Timothy A.4 aut
700	1	a Becker, Diane M.4 aut
700	1	a Becker, Lewis C.4 aut
700	1	a Berger, Klaus4 aut
700	1	a Bis, Joshua C.4 aut
700	1	a Boekholdt, S. Matthijs4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Braund, Peter S.4 aut
700	1	a Brown, Morris J.4 aut
700	1	a Burnett, Mary Susan4 aut
700	1	a Buysschaert, Ian4 aut
700	1	a Carlquist, John F.4 aut
700	1	a Chen, Li4 aut
700	1	a Cichon, Sven4 aut
700	1	a Codd, Veryan4 aut
700	1	a Davies, Robert W.4 aut
700	1	a Dedoussis, George4 aut
700	1	a Dehghan, Abbas4 aut
700	1	a Demissie, Serkalem4 aut
700	1	a Devaney, Joseph M.4 aut
700	1	a Diemert, Patrick4 aut
700	1	a Do, Ron4 aut
700	1	a Doering, Angela4 aut
700	1	a Eifert, Sandra4 aut
700	1	a El Mokhtari, Nour Eddine4 aut
700	1	a Ellis, Stephen G.4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Engert, James C.4 aut
700	1	a Epstein, Stephen E.4 aut
700	1	a de Faire, Ulfu Karolinska Institutet4 aut
700	1	a Fischer, Marcus4 aut
700	1	a Folsom, Aaron R.4 aut
700	1	a Freyer, Jennifer4 aut
700	1	a Gigante, Bruna4 aut
700	1	a Girelli, Domenico4 aut
700	1	a Gretarsdottir, Solveig4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Gulcher, Jeffrey R.4 aut
700	1	a Halperin, Eran4 aut
700	1	a Hammond, Naomi4 aut
700	1	a Hazen, Stanley L.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Horne, Benjamin D.4 aut
700	1	a Illig, Thomas4 aut
700	1	a Iribarren, Carlos4 aut
700	1	a Jones, Gregory T.4 aut
700	1	a Jukema, J. Wouter4 aut
700	1	a Kaiser, Michael A.4 aut
700	1	a Kaplan, Lee M.4 aut
700	1	a Kastelein, John J. P.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Knowles, Joshua W.4 aut
700	1	a Kolovou, Genovefa4 aut
700	1	a Kong, Augustine4 aut
700	1	a Laaksonen, Reijo4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Leander, Karinu Karolinska Institutet4 aut
700	1	a Lettre, Guillaume4 aut
700	1	a Li, Mingyao4 aut
700	1	a Lieb, Wolfgang4 aut
700	1	a Loley, Christina4 aut
700	1	a Lotery, Andrew J.4 aut
700	1	a Mannucci, Pier M.4 aut
700	1	a Maouche, Seraya4 aut
700	1	a Martinelli, Nicola4 aut
700	1	a McKeown, Pascal P.4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Merlini, Pier Angelica4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Morgan, Thomas4 aut
700	1	a Muehleisen, Thomas W.4 aut
700	1	a Muhlestein, Joseph B.4 aut
700	1	a Muenzel, Thomas4 aut
700	1	a Musunuru, Kiran4 aut
700	1	a nahrstaedt, Janja4 aut
700	1	a Nelson, Christopher P.4 aut
700	1	a Noethen, Markus M.4 aut
700	1	a Olivieri, Oliviero4 aut
700	1	a Patel, Riyaz S.4 aut
700	1	a Patterson, Chris C.4 aut
700	1	a Peters, Annette4 aut
700	1	a Peyvandi, Flora4 aut
700	1	a Qu, Liming4 aut
700	1	a Quyyumi, Arshed A.4 aut
700	1	a Rader, Daniel J.4 aut
700	1	a Rallidis, Loukianos S.4 aut
700	1	a Rice, Catherine4 aut
700	1	a Rosendaal, Frits R.4 aut
700	1	a Rubin, Diana4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Sampietro, M. Lourdes4 aut
700	1	a Sandhu, Manj S.4 aut
700	1	a Schadt, Eric4 aut
700	1	a Schaefer, Arne4 aut
700	1	a Schillert, Arne4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Schrezenmeir, Juergen4 aut
700	1	a Schwartz, Stephen M.4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Sivananthan, Mohan4 aut
700	1	a Sivapalaratnam, Suthesh4 aut
700	1	a Smith, Albert4 aut
700	1	a Smith, Tamara B.4 aut
700	1	a Snoep, Jaapjan D.4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a Spertus, John A.4 aut
700	1	a Stark, Klaus4 aut
700	1	a Stirrups, Kathy4 aut
700	1	a Stoll, Monika4 aut
700	1	a Tang, W. H. Wilson4 aut
700	1	a Tennstedt, Stephanie4 aut
700	1	a Thorgeirsson, Gudmundur4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Tomaszewski, Maciej4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a van Rij, Andre M.4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Wareham, Nick J.4 aut
700	1	a Wells, George A.4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Wild, Philipp S.4 aut
700	1	a Willenborg, Christina4 aut
700	1	a Witteman, Jaqueline C. M.4 aut
700	1	a Wright, Benjamin J.4 aut
700	1	a Ye, Shu4 aut
700	1	a Zeller, Tanja4 aut
700	1	a Ziegler, Andreas4 aut
700	1	a Cambien, Francois4 aut
700	1	a Goodall, Alison H.4 aut
700	1	a Cupples, L. Adrienne4 aut
700	1	a Quertermous, Thomas4 aut
700	1	a Maerz, Winfried4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Blankenberg, Stefan4 aut
700	1	a Ouwehand, Willem H.4 aut
700	1	a Hall, Alistair S.4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Thompson, John R.4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Roberts, Robert4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a O'Donnell, Christopher J.4 aut
700	1	a McPherson, Ruth4 aut
700	1	a Erdmann, Jeanette4 aut
700	1	a Samani, Nilesh J.4 aut
710	2	a Karolinska Institutetb Kardiovaskulär forskning - hypertoni4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 43:4, s. 153-333q 43:4<153-333x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.784y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3119261?pdf=render
856	4 8	u https://lup.lub.lu.se/record/1925030
856	4 8	u https://doi.org/10.1038/ng.784
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:122295667

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Av författaren/redakt...: Schunkert, Herib ...; Koenig, Inke R.; Kathiresan, Seka ...; Reilly, Muredach ...; Assimes, Themist ...; Holm, Hilma; visa fler...; Preuss, Michael; Stewart, Alexand ...; Barbalic, Maja; Gieger, Christia ...; Absher, Devin; Aherrahrou, Zouh ...; Allayee, Hooman; Altshuler, David; Anand, Sonia S.; Andersen, Karl; Anderson, Jeffre ...; Ardissino, Diego; Ball, Stephen G.; Balmforth, Antho ...; Barnes, Timothy ...; Becker, Diane M.; Becker, Lewis C.; Berger, Klaus; Bis, Joshua C.; Boekholdt, S. Ma ...; Boerwinkle, Eric; Braund, Peter S.; Brown, Morris J.; Burnett, Mary Su ...; Buysschaert, Ian; Carlquist, John ...; Chen, Li; Cichon, Sven; Codd, Veryan; Davies, Robert W ...; Dedoussis, Georg ...; Dehghan, Abbas; Demissie, Serkal ...; Devaney, Joseph ...; Diemert, Patrick; Do, Ron; Doering, Angela; Eifert, Sandra; El Mokhtari, Nou ...; Ellis, Stephen G ...; Elosua, Roberto; Engert, James C.; Epstein, Stephen ...; de Faire, Ulf; Fischer, Marcus; Folsom, Aaron R.; Freyer, Jennifer; Gigante, Bruna; Girelli, Domenic ...; Gretarsdottir, S ...; Gudnason, Vilmun ...; Gulcher, Jeffrey ...; Halperin, Eran; Hammond, Naomi; Hazen, Stanley L ...; Hofman, Albert; Horne, Benjamin ...; Illig, Thomas; Iribarren, Carlo ...; Jones, Gregory T ...; Jukema, J. Woute ...; Kaiser, Michael ...; Kaplan, Lee M.; Kastelein, John ...; Khaw, Kay-Tee; Knowles, Joshua ...; Kolovou, Genovef ...; Kong, Augustine; Laaksonen, Reijo; Lambrechts, Diet ...; Leander, Karin; Lettre, Guillaum ...; Li, Mingyao; Lieb, Wolfgang; Loley, Christina; Lotery, Andrew J ...; Mannucci, Pier M ...; Maouche, Seraya; Martinelli, Nico ...; McKeown, Pascal ...; Meisinger, Chris ...; Meitinger, Thoma ...; Melander, Olle; Merlini, Pier An ...; Mooser, Vincent; Morgan, Thomas; Muehleisen, Thom ...; Muhlestein, Jose ...; Muenzel, Thomas; Musunuru, Kiran; nahrstaedt, Janj ...; Nelson, Christop ...; Noethen, Markus ...; Olivieri, Olivie ...; Patel, Riyaz S.; Patterson, Chris ...; Peters, Annette; Peyvandi, Flora; Qu, Liming; Quyyumi, Arshed ...; Rader, Daniel J.; Rallidis, Loukia ...; Rice, Catherine; Rosendaal, Frits ...; Rubin, Diana; Salomaa, Veikko; Sampietro, M. Lo ...; Sandhu, Manj S.; Schadt, Eric; Schaefer, Arne; Schillert, Arne; Schreiber, Stefa ...; Schrezenmeir, Ju ...; Schwartz, Stephe ...; Siscovick, David ...; Sivananthan, Moh ...; Sivapalaratnam, ...; Smith, Albert; Smith, Tamara B.; Snoep, Jaapjan D ...; Soranzo, Nicole; Spertus, John A.; Stark, Klaus; Stirrups, Kathy; Stoll, Monika; Tang, W. H. Wils ...; Tennstedt, Steph ...; Thorgeirsson, Gu ...; Thorleifsson, Gu ...; Tomaszewski, Mac ...; Uitterlinden, An ...; van Rij, Andre M ...; Voight, Benjamin ...; Wareham, Nick J.; Wells, George A.; Wichmann, H-Eric ...; Wild, Philipp S.; Willenborg, Chri ...; Witteman, Jaquel ...; Wright, Benjamin ...; Ye, Shu; Zeller, Tanja; Ziegler, Andreas; Cambien, Francoi ...; Goodall, Alison ...; Cupples, L. Adri ...; Quertermous, Tho ...; Maerz, Winfried; Hengstenberg, Ch ...; Blankenberg, Ste ...; Ouwehand, Willem ...; Hall, Alistair S ...; Deloukas, Panos; Thompson, John R ...; Stefansson, Kari; Roberts, Robert; Thorsteinsdottir ...; O'Donnell, Chris ...; McPherson, Ruth; Erdmann, Jeanett ...; Samani, Nilesh J ...; visa färre...

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