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Dyskinesias followi...
Dyskinesias following neural transplantation in Parkinson's disease.
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- Hagell, Peter (author)
- Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine
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Piccini, Paola (author)
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- Björklund, Anders (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
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- Brundin, Patrik (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Rehncrona, Stig (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Widner, Håkan (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Crabb, Lesley (author)
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Pavese, Nicola (author)
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Oertel, Wolfgang H (author)
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Quinn, Niall (author)
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Brooks, David J (author)
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- Lindvall, Olle (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund
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(creator_code:org_t)
- 2002-06-03
- 2002
- English.
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In: Nature Neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 5:7, s. 627-628
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Abstract
Subject headings
Close
- Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Parkinson Disease : therapy
- Parkinson Disease : radionuclide imaging
- Neurons : transplantation
- Middle Age
- Mesencephalon : transplantation
- Mesencephalon : embryology
- Mesencephalon : cytology
- Hyperkinesis : etiology
- Hyperkinesis : diagnosis
- Human
- Dystonia : etiology
- Dystonia : diagnosis
- Dyskinesias : etiology
- Dyskinesias : diagnosis
- Disease Progression
- Cultured
- Cells
- Brain Tissue Transplantation : adverse effects
- Cell Division : physiology
- Postoperative Complications : diagnosis
- Postoperative Complications : etiology
- Putamen : physiopathology
- Putamen : radionuclide imaging
- Retrospective Studies
- Support
- Non-U.S. Gov't
- Time Factors
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Hagell, Peter
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Piccini, Paola
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Björklund, Ander ...
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Brundin, Patrik
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Rehncrona, Stig
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Widner, Håkan
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Crabb, Lesley
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Pavese, Nicola
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Oertel, Wolfgang ...
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Quinn, Niall
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Brooks, David J
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Lindvall, Olle
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Neuroscie ...
- By the university
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Lund University