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Composite GRFS and ...
Composite GRFS and CRFS Outcomes After Adult Alternative Donor HCT
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- Mehta, Rohtesh S. (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
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- Holtan, Shernan G. (författare)
- Univ Minnesota, Minneapolis, MN USA.
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- Wang, Tao (författare)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Equity, Milwaukee, WI 53226 USA.
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- Hemmer, Michael T. (författare)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.
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- Spellman, Stephen R. (författare)
- Be Match, CIBMTR, Natl Marrow Donor Program, Minneapolis, MN USA.
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- Arora, Mukta (författare)
- Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
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- Couriel, Daniel R. (författare)
- Utah Blood & Marrow Transplant Program, Salt Lake City, UT USA.
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- Alousi, Amin M. (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
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- Pidala, Joseph (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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- Abdel-Azim, Hisham (författare)
- Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Div Hematol Oncol & Blood & Marrow Transplanta, Los Angeles, CA 90007 USA.
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- Agrawal, Vaibhav (författare)
- Indiana Univ, Sch Med, Div Hematol Oncol, Indianapolis, IN USA.
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- Ahmed, Ibrahim (författare)
- Childrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA.
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- Al-Homsi, A. Samer (författare)
- NYU, Langone Med Ctr, New York, NY USA.
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- Aljurf, Mahmoud (författare)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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- Antin, Joseph H. (författare)
- Dana Farber Canc Inst, Dept Med Oncol, Div Hematol Malignancies, Boston, MA 02115 USA.
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- Askar, Medhat (författare)
- Baylor Univ, Med Ctr, Dept Pathol & Lab Med, Dallas, TX USA.
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- Auletta, Jeffery J. (författare)
- Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Host Def Program, Columbus, OH USA.
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- Bhatt, Vijaya Raj (författare)
- Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.
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- Chee, Lynette (författare)
- Royal Melbourne Hosp, City Campus, Melbourne, Vic, Australia.
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- Chhabra, Saurabh (författare)
- Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA.
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- Daly, Andrew (författare)
- Tom Baker Canc Clin, Calgary, AB, Canada.
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- DeFilipp, Zachariah (författare)
- Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.
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- Gajewski, James (författare)
- Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
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- Gale, Robert Peter (författare)
- Imperial Coll London, Div Expt Med, Dept Med, Hematol Res Ctr, London, England.
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- Gergis, Usama (författare)
- New York Presbyterian Hosp, Dept Med Oncol, Hematolg Malignancies & Bone Marrow Transplant, Weill Cornell Med Ctr, New York, NY USA.
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- Hematti, Peiman (författare)
- Univ Wisconsin Hosp & Clin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI 53792 USA.
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- Hildebrandt, Gerhard C. (författare)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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- Hogan, William J. (författare)
- Mayo Clin, Div Hematol Bone Marrow Transplantat, Rochester, MN USA.
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- Inamoto, Yoshihiro (författare)
- Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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- Martino, Rodrigo (författare)
- Hosp Santa Creu Sant & Pau, Div Clin Hematol, Barcelona, Spain.
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- Majhail, Navneet S. (författare)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Marks, David I. (författare)
- Univ Hosp Bristol, Adult Bone Marrow Transplant, Natl Hlth Serv Trust, Bristol, Avon, England.
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- Nishihori, Taiga (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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- Olsson, Richard (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Translat Cell Therapy Res, Clintec, Stockholm, Sweden.
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- Pawarode, Attaphol (författare)
- Univ Michigan, Sch Med, Blood & Marrow Transplantat Program, Div Hematol Oncol,Dept Internal Med, Ann Arbor, MI USA.
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- Diaz, Miguel Angel (författare)
- Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.
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- Prestidge, Tim (författare)
- Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.
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- Rangarajan, Hemalatha G. (författare)
- Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Host Def Program, Columbus, OH USA.
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- Ringden, Olle (författare)
- Karolinska Institutet
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- Saad, Ayman (författare)
- Ohio State Univ, Div Hematol, Columbus, OH 43210 USA.
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Hematol Oncol, Nashville, TN 37232 USA.
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- Schoemans, Helene (författare)
- Univ Hosp Leuven, Leuven, Belgium.;Katholieke Univ Leuven, Leuven, Belgium.
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- Seo, Sachiko (författare)
- Natl Canc Res Ctr East, Dept Hematol & Oncol, Chiba, Japan.
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- Schultz, Kirk R. (författare)
- Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada.
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- Solh, Melhem (författare)
- Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
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- Spitzer, Thomas (författare)
- Tom Baker Canc Clin, Calgary, AB, Canada.
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- Storek, Jan (författare)
- Univ Calgary, Dept Med, Calgary, AB, Canada.
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- Teshima, Takanori (författare)
- Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan.
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- Verdonck, Leo F. (författare)
- Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.
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- Wirk, Baldeep (författare)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
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- Yared, Jean A. (författare)
- Univ Maryland, Blood & Marrow Transplantat Program, Greenebaum Comprehens Canc Ctr, Div Hematol Oncol,Dept Med, Baltimore, MD 21201 USA.
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- Cahn, Jean-Yves (författare)
- CHU Grenoble Alpes, Dept Hematol, Grenoble, France.
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- Weisdorf, Daniel J. (författare)
- Univ Minnesota, Minneapolis, MN USA.
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Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA Univ Minnesota, Minneapolis, MN USA. (creator_code:org_t)
- American Society of Clinical Oncology (ASCO), 2020
- 2020
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 38:18, s. 2062-2076
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- PURPOSE There is no consensus on the best choice of an alternative donor (umbilical cord blood [UCB], haploidentical, one-antigen mismatched [7/8]-bone marrow [BM], or 7/8-peripheral blood [PB]) for hematopoietic cell transplantation (HCT) for patients lacking an HLA-matched related or unrelated donor.METHODS We report composite end points of graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) and chronic GVHD (cGVHD)-free relapse-free survival (CRFS) in 2,198 patients who underwent UCB (n = 838), haploidentical (n = 159), 7/8-BM (n = 241), or 7/8-PB (n = 960) HCT. All groups were divided by myeloablative conditioning (MAC) intensity or reduced intensity conditioning (RIC), except haploidentical group in which most received RIC. To account for multiple testing, P < .0071 in multivariable analysis and P < .00025 in direct pairwise comparisons were considered statistically significant.RESULTS In multivariable analysis, haploidentical group had the best GRFS, CRFS, and overall survival (OS). In the direct pairwise comparison of other groups, among those who received MAC, there was no difference in GRFS or CRFS among UCB, 7/8-BM, and 7/8-PB with serotherapy (alemtuzumab or antithymocyte globulin) groups. In contrast, the 7/8-PB without serotherapy group had significantly inferior GRFS, higher cGVHD, and a trend toward worse CRFS (hazard ratio [HR], 1.38; 95% CI, 1.13 to 1.69; P = .002) than the 7/8-BM group and higher cGVHD and trend toward inferior CRFS (HR, 1.36; 95% CI, 1.14 to 1.63; P = .0006) than the UCB group. Among patients with RIC, all groups had significantly inferior GRFS and CRFS compared with the haploidentical group.CONCLUSION Recognizing the limitations of a registry retrospective analysis and the possibility of center selection bias in choosing donors, our data support the use of UCB, 7/8-BM, or 7/8-PB (with serotherapy) grafts for patients undergoing MAC HCT and haploidentical grafts for patients undergoing RIC HCT. The haploidentical group had the best GRFS, CRFS, and OS of all groups.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Mehta, Rohtesh S ...
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Holtan, Shernan ...
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Wang, Tao
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Hemmer, Michael ...
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Spellman, Stephe ...
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Arora, Mukta
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Couriel, Daniel ...
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Alousi, Amin M.
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Pidala, Joseph
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Abdel-Azim, Hish ...
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Agrawal, Vaibhav
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Ahmed, Ibrahim
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Al-Homsi, A. Sam ...
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Aljurf, Mahmoud
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Antin, Joseph H.
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Askar, Medhat
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Auletta, Jeffery ...
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Bhatt, Vijaya Ra ...
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Chee, Lynette
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Chhabra, Saurabh
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Daly, Andrew
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DeFilipp, Zachar ...
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Gajewski, James
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Gale, Robert Pet ...
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Gergis, Usama
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Hematti, Peiman
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Hildebrandt, Ger ...
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Hogan, William J ...
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Inamoto, Yoshihi ...
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Martino, Rodrigo
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Majhail, Navneet ...
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Marks, David I.
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Nishihori, Taiga
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Olsson, Richard
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Pawarode, Attaph ...
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Diaz, Miguel Ang ...
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Prestidge, Tim
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Rangarajan, Hema ...
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Ringden, Olle
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Saad, Ayman
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Savani, Bipin N.
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Schoemans, Helen ...
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Seo, Sachiko
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Schultz, Kirk R.
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Solh, Melhem
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Spitzer, Thomas
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Storek, Jan
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Teshima, Takanor ...
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Verdonck, Leo F.
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Wirk, Baldeep
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Yared, Jean A.
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Cahn, Jean-Yves
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Weisdorf, Daniel ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Journal of Clini ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet