Sökning: WFRF:(Zoma Asad A.) > Cancer risk in syst...
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000 | 05323naa a2200865 4500 | |
001 | oai:lup.lub.lu.se:e4f61ce6-068f-4087-a6a7-a35d1c7a04df | |
003 | SwePub | |
008 | 160401s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/39311652 URI |
024 | 7 | a https://doi.org/10.1016/j.jaut.2012.12.0092 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Bernatsky, Sasha4 aut |
245 | 1 0 | a Cancer risk in systemic lupus: An updated international multi-centre cohort study |
264 | 1 | b Elsevier BV,c 2013 |
520 | a Objective: To update estimates of cancer risk in SLE relative to the general population. Methods: A multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Results: Across 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95% confidence interval, CI, 2.48, 3.63), particularly non-Hodgkin's lymphoma, NHL (SIR 4.39, 95% CI 3.46, 5.49) and leukemia. In addition, increased risks of cancer of the vulva (SIR 3.78, 95% CI 1.52, 7.78), lung (SIR 1.30, 95% CI 1.04, 1.60), thyroid (SIR 1.76, 95% CI 1.13, 2.61) and possibly liver (SIR 1.87, 95% CI 0.97, 3.27) were suggested. However, a decreased risk was estimated for breast (SIR 0.73, 95% CI 0.61-0.88), endometrial (SIR 0.44, 95% CI 0.23-0.77), and possibly ovarian cancers (0.64, 95% Cl 0.34-1.10). The variability of comparative rates across different cancers meant that only a small increased risk was estimated across all cancers (SIR 1.14, 95% CI 1.05, 1.23). Conclusion: These data estimate only a small increased risk in SLE (versus the general population) for cancer over-all. However, there is clearly an increased risk of NHL and cancers of the vulva, lung, thyroid, and possibly liver. It remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Similarly, the etiology of the decreased breast, endometrial, and possibly ovarian cancer risk is uncertain, though investigations are ongoing. (C) 2013 Elsevier Ltd. All rights reserved. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a Systemic lupus erythematosus | |
653 | a Epidemiology | |
653 | a Treatment | |
653 | a Disease activity | |
700 | 1 | a Ramsey-Goldman, Rosalind4 aut |
700 | 1 | a Labrecque, Jeremy4 aut |
700 | 1 | a Joseph, Lawrence4 aut |
700 | 1 | a Boivin, Jean-Francois4 aut |
700 | 1 | a Petri, Michelle4 aut |
700 | 1 | a Zoma, Asad4 aut |
700 | 1 | a Manzi, Susan4 aut |
700 | 1 | a Urowitz, Murray B.4 aut |
700 | 1 | a Gladman, Dafna4 aut |
700 | 1 | a Fortin, Paul R.4 aut |
700 | 1 | a Ginzler, Ellen4 aut |
700 | 1 | a Yelin, Edward4 aut |
700 | 1 | a Bae, Sang-Cheol4 aut |
700 | 1 | a Wallace, Daniel J.4 aut |
700 | 1 | a Edworthy, Steven4 aut |
700 | 1 | a Jacobsen, Soren4 aut |
700 | 1 | a Gordon, Caroline4 aut |
700 | 1 | a Dooley, Mary Anne4 aut |
700 | 1 | a Peschken, Christine A.4 aut |
700 | 1 | a Hanly, John G.4 aut |
700 | 1 | a Alarcon, Graciela S.4 aut |
700 | 1 | a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni |
700 | 1 | a Ruiz-Irastorza, Guillermo4 aut |
700 | 1 | a Isenberg, David4 aut |
700 | 1 | a Rahman, Anisur4 aut |
700 | 1 | a Witte, Torsten4 aut |
700 | 1 | a Aranow, Cynthia4 aut |
700 | 1 | a Kamen, Diane L.4 aut |
700 | 1 | a Steinsson, Kristjan4 aut |
700 | 1 | a Askanase, Anca4 aut |
700 | 1 | a Barr, Susan4 aut |
700 | 1 | a Criswell, Lindsey A.4 aut |
700 | 1 | a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst |
700 | 1 | a Patel, Neha M.4 aut |
700 | 1 | a Senecal, Jean-Luc4 aut |
700 | 1 | a Zummer, Michel4 aut |
700 | 1 | a Pope, Janet E.4 aut |
700 | 1 | a Ensworth, Stephanie4 aut |
700 | 1 | a El-Gabalawy, Hani4 aut |
700 | 1 | a McCarthy, Timothy4 aut |
700 | 1 | a Dreyer, Lene4 aut |
700 | 1 | a Sibley, John4 aut |
700 | 1 | a St Pierre, Ivan4 aut |
700 | 1 | a Clarke, Ann E.4 aut |
710 | 2 | a Reumatologi och molekylär skelettbiologib Sektion III4 org |
773 | 0 | t Journal of Autoimmunityd : Elsevier BVg 42, s. 130-135q 42<130-135x 0896-8411 |
856 | 4 | u http://dx.doi.org/10.1016/j.jaut.2012.12.009y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc3646904?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/3931165 |
856 | 4 8 | u https://doi.org/10.1016/j.jaut.2012.12.009 |
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