WFRF:(Carlström Andreas)
Search: WFRF:(Carlström Andreas) > (2000-2024) > Insertion Defects o...
- 22 of 24
- Previous record
- Next record
- To hitlist
Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System
-
- Vargas Möller-Hergt, Braulio (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
- Carlström, Andreas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
- Suhm, Tamara (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
- show more...
- show less...
- (creator_code:org_t)
- 2018-10-17
- 2018
- English.
- In: Cells. - : MDPI AG. - 2073-4409. ; 7:10
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either synthesized in the cytosol and imported into the different compartments of the organelle or directly produced in the mitochondrial matrix. To ensure proteostasis, proteins are monitored by the mitochondrial quality control system, which will degrade non-native polypeptides. Defective mitochondrial membrane proteins are degraded by membrane-bound AAA-proteases. These proteases are regulated by factors promoting protein turnover or preventing their degradation. Here we determined genetic interactions between the mitoribosome receptors Mrx15 and Mba1 with the quality control system. We show that simultaneous absence of Mrx15 and the regulators of the i-AAA protease Mgr1 and Mgr3 provokes respiratory deficiency. Surprisingly, mutants lacking Mrx15 were more tolerant against proteotoxic stress. Furthermore, yeast cells became hypersensitive against proteotoxic stress upon deletion of MBA1. Contrary to Mrx15, Mba1 cooperates with the regulators of the m-AAA and i-AAA proteases. Taken together, these results suggest that membrane protein insertion and mitochondrial AAA-proteases are functionally coupled, possibly reflecting an early quality control step during mitochondrial protein synthesis.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- mitochondria
- mitochondrial quality control
- membrane protein insertion
- membrane-bound AAA proteases
- Biochemistry
- biokemi
Publication and Content Type
- ref (subject category)
- art (subject category)
- 22 of 24
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Vargas Möller-He ...
- Carlström, Andre ...
- Suhm, Tamara
- Ott, Martin
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- Cells
- By the university
- Stockholm University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
