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WFRF:(De Michele Giuseppe)
 

Sökning: WFRF:(De Michele Giuseppe) > (2020-2024) > Cardiac biomarkers ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004053naa a2200613 4500
001oai:DiVA.org:uu-489752
003SwePub
008221204s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4897522 URI
0247 a https://doi.org/10.2459/jcm.00000000000012812 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Vergaro, Giuseppe4 aut
2451 0a Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease
264 c 2021-11-26
264 1b Wolters Kluwer,c 2021
338 a print2 rdacarrier
520 a Aim: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).Methods: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.Results: Patients had a median age of 66 years (interquartile interval 57–74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487–2725), 17 ng/l (9–31) and 30 ng/ml (22–44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5–2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9–2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.Conclusions: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Aimo, Alberto4 aut
7001 a Januzzi, James L.4 aut
7001 a Richards, A. Mark4 aut
7001 a Lam, Carolyn S.P.4 aut
7001 a Latini, Roberto4 aut
7001 a Staszewsky, Lidia4 aut
7001 a Anand, Inder S.4 aut
7001 a Ueland, Thor4 aut
7001 a Brunner-La Rocca, Hans-Peter4 aut
7001 a Bayes-Genis, Antoni4 aut
7001 a Lupón, Josep4 aut
7001 a de Boer, Rudolf A.4 aut
7001 a Yoshihisa, Akiomi4 aut
7001 a Takeishi, Yasuchika4 aut
7001 a Gustafsson, Ida4 aut
7001 a Eggers, Kai M.,d 1962-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)kaieg561
7001 a Huber, Kurt4 aut
7001 a Gamble, Greg D.4 aut
7001 a Leong, Kui Toh Gerard4 aut
7001 a Yeo, Poh Shuan Daniel4 aut
7001 a Ong, Hean Yee4 aut
7001 a Jaufeerally, Fazlur4 aut
7001 a Ng, Tze P.4 aut
7001 a Troughton, Richard4 aut
7001 a Doughty, Robert N.4 aut
7001 a Emdin, Michele4 aut
7001 a Passino, Claudio4 aut
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t Journal of Cardiovascular Medicined : Wolters Kluwerg 23:1, s. 28-36q 23:1<28-36x 1558-2027x 1558-2035
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489752
8564 8u https://doi.org/10.2459/jcm.0000000000001281

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