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FältnamnIndikatorerMetadata
00009223naa a2201033 4500
001oai:DiVA.org:oru-38045
003SwePub
008141024s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:129817169
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-380452 URI
0247 a https://doi.org/10.1038/ng.30932 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1298171692 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Heap, Graham A.u IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England; Precis Med, Univ Exeter, Exeter, England4 aut
2451 0a HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
264 c 2014-09-14
264 1b Nature Publishing Group,c 2014
338 a print2 rdacarrier
500 a Funding Agencies:International Serious Adverse Events Consortium (iSAEC)Crohn's and Colitis UKWellcome Trust Institutional Strategic Support Award 
520 a Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 x 10(-16)). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the H LA region identified association with the HLA-DQA1*02:01-HLA-DRB1*07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Genetik
653 a Genetics
7001 a Weedon, Michael N.u Precision medicine, Exeter Medical School, University of Exeter, Exeter, England4 aut
7001 a Bewshea, Claire M.u IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England; Precision Med Exeter, Univ Exeter, Exeter, England4 aut
7001 a Singh, Abheyu IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England4 aut
7001 a Chen, Mianu Oxford Transplant Ctr, Royal Devon & Exeter Hosp, Oxford, England4 aut
7001 a Satchwel, Jack B.u Oxford Transplant Ctr, Oxford Univ Hosp Natl Hlth Serv NHS Trust, Oxford, England4 aut
7001 a Vivian, Julian P.u Sch Biomed Sci, Dept Biochem & Mol Biol, Monash Univ, Clayton Vic, Australia4 aut
7001 a So, Kenjiu IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England4 aut
7001 a Dubois, Patrick C.u Dept Gastroenterol, Kings Coll Hosp, London, England4 aut
7001 a Andrews, Jane M.u Dept Gastroenterol, IBD Serv, Adelaide SA, Australia; Royal Adelaide Hosp, Univ Adelaide, Adelaide SA, Australia4 aut
7001 a Annese, Vitou Div Gastroenterol, Azienda Osped, Univ Careggi, Florence, Italy4 aut
7001 a Bampton, Peteru Flinders Med Ctr, Flinders Univ South Australia, Adelaide SA, Australia4 aut
7001 a Barnardo, Martinu Oxford Transplant Ctr, Oxford Univ Hosp Natl Hlth Serv NHS Trust, Oxford, England4 aut
7001 a Bell, Sallyu Dept Gastroenterol, St Vincent Hosp, Fitzroy Vic, Australia4 aut
7001 a Cole, Andyu Royal Derby Hosp, Derby, England4 aut
7001 a Connor, Susan J.u Dept Gastroenterol & Hepatol, Liverpool Hosp, Sydney NSW, Australia4 aut
7001 a Creed, Tomu Joint Clin Res Unit, Univ Hosp Bristol NHS Fdn Trust, Bristol, England4 aut
7001 a Cummings, Fraser R.u Dept Gastroenterol, Univ Hosp Southampton NHS Fdn Trust, Southampton, England4 aut
7001 a D'Amato, Maurou Karolinska Institutet4 aut
7001 a Daneshmend, Tawfique K.u IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England4 aut
7001 a Fedorak, Richard N.u Div Gastroenterol, Univ Alberta, Edmonton AB, Canada4 aut
7001 a Florin, Timothy H.u Sch Med, Univ Queensland, South Brisbane Qld, Australia4 aut
7001 a Gaya, Daniel R.u Gastroenterol Unit, Glasgow Royal Infirm, Glasgow, UK4 aut
7001 a Greig, Emmau Dept Gastroenterol, Taunton & Somerset NHS Fdn Trust, Taunton, England4 aut
7001 a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)jshn
7001 a Hart, Alisau Dept Med, St Marks Hosp, London, England; Acad Inst, North West London Hosp NHS Trust, London, England4 aut
7001 a Irving, Peter M.u Dept Gastroenterol, Guys & St Thomas NHS Fdn Trust, London, England4 aut
7001 a Jones, Garethu Dept Gastroenterol, Western Gen Hosp, Edinburgh, UK4 aut
7001 a Karban, Amiru Dept Gastroenterol, Rambam Med Ctr, Haifa, Israel4 aut
7001 a Lawrance, Ian C.u Ctr Inflammatory Bowel Dis, Fremantle Hosp, Univ Western Australia, Fremantle WA, Australia4 aut
7001 a Lee, James C.u Dept Gastroenterol, Cambridge Univ Hosp NHS Trust, Cambridge, England4 aut
7001 a Lees, Charlieu Dept Gastroenterol, Western Gen Hosp, Edinburgh, UK4 aut
7001 a Lev-Tzion, Raffiu Paediatr Gastroenterol & Nutr Unit, Shaare Zedek Med Ctr, Jerusalem, Israel4 aut
7001 a Lindsay, Jamesu Dept Gastroenterol, Barts & London NHS Trust, London, England4 aut
7001 a Mansfield, Johnu Dept Gastroenterol, Newcastle Univ Hosp NHS Trust, Newcastle NSW, Australia4 aut
7001 a Mawdsley, Joelu Dept Gastroenterol, West Middlesex Univ Hosp NHS Trust, Isleworth, England4 aut
7001 a Mazhar, Ziau Dept Gastroenterol, Basildon & Thurrock Hosp NHS Trust, Basildon, England4 aut
7001 a Parkes, Milesu Dept Gastroenterol, Cambridge Univ Hosp NHS Trust, Cambridge, England4 aut
7001 a Parnell, Kirstieu Precision Med Exeter, Univ Exeter, Exeter, England4 aut
7001 a Orchard, Timothy R.u Dept Med, Imperial Coll Healthcare NHS, London, England4 aut
7001 a Radford-Smith, Grahamu Dept Gastroenterol, Royal Brisbane & Womens Hosp, Brisbane Qld, Australia; IBD Grp, Queensland Inst Med Res, Brisbane Qld, Australia; Sch Med, Univ Queensland, Brisbane Qld, Australia4 aut
7001 a Russell, Richard K.u Dept Paediat Gastroenterol, Yorkhill Hosp, Glasgow, UK4 aut
7001 a Reffitt, Davidu Dept Gastroenterol, Lewisham & Greenwich NHS Trust, London, England4 aut
7001 a Satsangi, Jacku Dept Gastroenterol, Western Gen Hosp, Edinburgh, UK4 aut
7001 a Silverberg, Mark S.u Zane Cohen Ctr Digest Dis, Inflammatory Bowel Dis Grp, Mt Sinai Hosp, Toronto ON, Canada4 aut
7001 a Sturniolo, Giacomo C.u Univ Padua, Padua, Italy4 aut
7001 a Tremelling, Marku Dept Gastroenterol, Norfolk & Norwich Hosp NHS Trust, Norwich, England4 aut
7001 a Tsianos, Epameinondas V.u Fac Med, Div Internal Med 1, Univ Ioannina, Ioannina, Greece; Fac Med, Div Gastroenterol, Univ Ioannina, Ioannina, Greece4 aut
7001 a van Heel, David A.u Barts & London Sch Med & Dent, Blizard Inst, Queen Mary Univ, London, England4 aut
7001 a Walsh, Alissau Dept Gastroenterol, St Vincents Hosp, Sydney NSW, Australia4 aut
7001 a Watermeyer, Gillu Gastrointestinal Clin, Groote Schuur Hosp, Cape Town, South Africa4 aut
7001 a Weersma, Rinse K.u Dept Gastroenterol & Hepatol, Univ Med Ctr, Groningen, Netherlands; Univ Groningen, Groningen, Netherlands4 aut
7001 a Zeissig, Sebastianu Dept Internal Med, Univ Med Ctr Schleswig Holstein, Kiel, Germany4 aut
7001 a Rossjohn, Jamieu Sch Biomed Sci, Dept Biochem & Mol Biol, Monash Univ, Clayton Vic, Australia4 aut
7001 a Holden, Arthur L.u Int Serious Adverse Events Consortium, Chicago IL, USA4 aut
7001 a Ahmad, Tariqu IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England; Precision Med, Univ Exeter, Exeter, England4 aut
7102 a IBD Pharmacogenet, Royal Devon & Exeter Hosp, Exeter, England; Precis Med, Univ Exeter, Exeter, Englandb Precision medicine, Exeter Medical School, University of Exeter, Exeter, England4 org
7730 t Nature Geneticsd : Nature Publishing Groupg 46:10, s. 1131-1134q 46:10<1131-1134x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc6379053?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38045
8564 8u https://doi.org/10.1038/ng.3093
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:129817169

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