Local Diameter, Wall Stress, and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms

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Local Diameter, Wall Stress, and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms

Martufi, Giampaolo (författare): KTH,Hållfasthetslära (Inst.),University of Calgary, Canada

Liljeqvist, Moritz Lindquist (författare): Karolinska Institutet

Sakalihasan, Natzi (författare)

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Panuccio, Giuseppe (författare)

Hultgren, Rebecka (författare): Karolinska Institutet

Roy, Joy (författare): Karolinska Institutet

Gasser, T. Christian (författare): KTH,Hållfasthetslära (Inst.)

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KTH Hållfasthetslära (Inst) (creator_code:org_t)

2016-07-20
2016
Engelska.
Ingår i: Journal of Endovascular Therapy. - : Sage Publications. - 1526-6028 .- 1545-1550. ; 23:6, s. 957-966

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Purpose: To investigate the influence of the local diameter, the intraluminal thrombus (ILT) thickness, and wall stress on the local growth rate of abdominal aortic aneurysms. Methods: The infrarenal aortas of 90 asymptomatic abdominal aortic aneurysm (AAA) patients (mean age 70 years; 77 men) were retrospectively reconstructed from at least 2 computed tomography angiography scans (median follow-up of 1 year) and biomechanically analyzed with the finite element method. Each individual AAA model was automatically sliced orthogonally to the lumen centerline and represented by 100 cross sections with corresponding diameters, ILT thicknesses, and wall stresses. The data were grouped according to these parameters for comparison of differences among the variables. Results: Diameter growth was continuously distributed over the entire aneurysm sac, reaching absolute and relative median peaks of 3.06 mm/y and 7.3%/y, respectively. The local growth rate was dependent on the local baseline diameter, the local ILT thickness, and for wall segments not covered by ILT, also on the local wall stress level (all p<0.001). For wall segments that were covered by a thick ILT layer, wall stress did not affect the growth rate (p=0.08). Conclusion: Diameter is not only a strong global predictor but also a local predictor of aneurysm growth. In addition, and independent of the diameter, the ILT thickness and wall stress (for the ILT-free wall) also influence the local growth rate. The high stress sensitivity of nondilated aortic walls suggests that wall stress peaks could initiate AAA formation. In contrast, local diameters and ILT thicknesses determine AAA growth for dilated and ILT-covered aortic walls.

Nyckelord

abdominal aortic aneurysm
aneurysm diameter
aneurysm growth
finite element analysis
intraluminal thrombus
mechanical stress
wall stress

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Av författaren/redakt...: Martufi, Giampao ...; Liljeqvist, Mori ...; Sakalihasan, Nat ...; Panuccio, Giusep ...; Hultgren, Rebeck ...; Roy, Joy; visa fler...; Gasser, T. Chris ...; visa färre...

Artiklar i publikationen: Journal of Endov ...

Av lärosätet: Kungliga Tekniska Högskolan; Karolinska Institutet

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