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  • Jonsson, E.Quantify Res, Hantverkargatan 8, SE-11221 Stockholm, Sweden.,Quantify Research AB,Quantify Research, Stockholm, Sweden (författare)

A health economic simulation model for the clinical management of osteoporosis

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2017-12-01
  • Springer Science and Business Media LLC,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-351263
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351263URI
  • https://doi.org/10.1007/s00198-017-4325-4DOI
  • https://lup.lub.lu.se/record/0d1afe71-0222-4dc0-8800-915a51ec83deURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137801075URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144030URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:  Medtronic
  • The objective was to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice. Results showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings.IntroductionThe purpose of this study is to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice.MethodsThe analysis was carried out using a model that simulates the individual patients considered for pharmacological treatment during 1 year and their projected osteoporosis treatment pathway, quality-adjusted life years (QALYs) and costs over their remaining lifetime. All patients regardless of treatment or no treatment were simulated. Information on current management of osteoporosis in terms of patient characteristics and treatment patterns were derived from a Swedish osteoporosis research database based on national registers and patient records. Current (standard) clinical management was compared with alternative scenarios mirroring Swedish treatment guidelines.ResultsThe national burden in terms of lost QALYs was estimated at 14,993 QALYs and the total economic cost at €776M. Scenario analyses showed that 382–3864 QALYs could be gained at a cost/QALY ranging from cost-saving to €31368, depending on the scenario. The margin of investment, i.e. the maximum amount that could be invested in the healthcare system to achieve these improvements up to the limit of the willingness to pay/QALY, was estimated at €199M on a population level (€3,634/patient).ConclusionsThe analysis showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings. From a cost-effectiveness perspective, there is also considerable room for investment to achieve these improvements in the management of osteoporosis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hansson-Hedblom, A.Quantify Res, Hantverkargatan 8, SE-11221 Stockholm, Sweden.,Quantify Research AB,Quantify Research, Stockholm, Sweden (författare)
  • Ljunggren, ÖstenUppsala universitet,Endokrinologi och mineralmetabolism,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)osteljun (författare)
  • Åkesson, K.Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,University of Sheffield, Sheffield, UK; Catholic University of Australia, Melbourne, Australia,Australian Catholic University,Department of Clinical Sciences, Clinical and Molecular Osteoporosis Unit, Lund University, Malmö, Sweden(Swepub:lu)orto-kak (författare)
  • Spångeus, Anna,1975-Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)annsp18 (författare)
  • Kanis, J. A.Univ Sheffield, Sheffield, S Yorkshire, England.;Catholic Univ Australia, Melbourne, Vic, Australia. (författare)
  • Borgstrom, F.Karolinska Institutet,Karolinska Institute,Quantify Research AB,Quantify Research, Stockholm; Karolinska Institutet, Stockholm, Sweden (författare)
  • Quantify Res, Hantverkargatan 8, SE-11221 Stockholm, Sweden.Quantify Research AB (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Osteoporosis International: Springer Science and Business Media LLC29:3, s. 545-5550937-941X1433-2965

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