WFRF:(Lind Anders E.)
Sökning: WFRF:(Lind Anders E.) > Shape abnormalities...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06665naa a2201333 4500 | |
| 001 | oai:gup.ub.gu.se/226736 | |
| 003 | SwePub | |
| 008 | 240528s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:130265253 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2267362 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jagp.2013.04.0112 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1302652532 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Macfarlane, M. D.4 aut |
| 245 | 1 0 | a Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: Results from a subset of the ladis study |
| 264 | 1 | b Elsevier BV,c 2015 |
| 520 | a Objective Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction. Methods Magnetic resonance imaging scans and clinical gait/balance data (scores from the Short Physical Performance Battery [SPPB]) were sourced from 66 subjects in the previously published LADIS trial, performed in nondisabled individuals older than age 65 years with WMHs at study entry. Data were obtained at study entry and at 3-year follow-up. Caudate nuclei and putamina were manually traced using a previously published method and volumes calculated. The relationships between volume and physical performance on the SPPB were investigated with shape analysis using the spherical harmonic shape description toolkit. Results There was no correlation between the severity of WMHs and striatal volumes. Caudate nuclei volume correlated with performance on the SPPB at baseline but not at follow-up, with subsequent shape analysis showing left caudate changes occurred in areas corresponding to inputs of the dorsolateral prefrontal, premotor, and motor cortex. There was no correlation between putamen volumes and performance on the SPPB. Conclusion Disruption in frontostriatal circuits may play a role in mediating poorer physical performance in individuals with WMHs. Striatal volume and shape changes may be suitable biomarkers for functional changes in this population. © 2015 American Association for Geriatric Psychiatry. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a caudate nucleus | |
| 653 | a gait | |
| 653 | a MRI | |
| 653 | a Striatum | |
| 653 | a white matter disease | |
| 700 | 1 | a Looi, J. C. L.4 aut |
| 700 | 1 | a Walterfang, M.4 aut |
| 700 | 1 | a Spulber, G.u Karolinska Institutet4 aut |
| 700 | 1 | a Velakoulis, D.4 aut |
| 700 | 1 | a Styner, M.4 aut |
| 700 | 1 | a Crisby, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Örndahl, E.4 aut |
| 700 | 1 | a Erkinjuntti, T.4 aut |
| 700 | 1 | a Waldemar, G.4 aut |
| 700 | 1 | a Garde, E.4 aut |
| 700 | 1 | a Hennerici, M. G.4 aut |
| 700 | 1 | a Bäzner, H.4 aut |
| 700 | 1 | a Blahak, C.4 aut |
| 700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xwaand |
| 700 | 1 | a Wahlund, L. O.u Karolinska Institutet4 aut |
| 700 | 1 | a Pohjasvaara, T.4 aut |
| 700 | 1 | a Pihanen, P.4 aut |
| 700 | 1 | a Ylikoski, R.4 aut |
| 700 | 1 | a Jokinen, H.4 aut |
| 700 | 1 | a Somerkoski, M. M.4 aut |
| 700 | 1 | a Mäntylä, R.4 aut |
| 700 | 1 | a Salonen, O.4 aut |
| 700 | 1 | a Fazekas, F.4 aut |
| 700 | 1 | a Schmidt, R.4 aut |
| 700 | 1 | a Ropele, S.4 aut |
| 700 | 1 | a Rous, B.4 aut |
| 700 | 1 | a Petrovic, K.4 aut |
| 700 | 1 | a Garmehi, U.4 aut |
| 700 | 1 | a Seewann, A.4 aut |
| 700 | 1 | a Ferro, J. M.4 aut |
| 700 | 1 | a Verdelho, A.4 aut |
| 700 | 1 | a Madureira, S.4 aut |
| 700 | 1 | a Moleiro, C.4 aut |
| 700 | 1 | a Scheltens, P.4 aut |
| 700 | 1 | a Van Straaten, I.4 aut |
| 700 | 1 | a Barkhof, F.4 aut |
| 700 | 1 | a Gouw, A.4 aut |
| 700 | 1 | a van der Flier, W.4 aut |
| 700 | 1 | a Jonsson, M.4 aut |
| 700 | 1 | a Lind, K.4 aut |
| 700 | 1 | a Nordlund, A.4 aut |
| 700 | 1 | a Rolstad, S.4 aut |
| 700 | 1 | a Isblad, I.4 aut |
| 700 | 1 | a Pettersson, A.4 aut |
| 700 | 1 | a Amberla, K.4 aut |
| 700 | 1 | a Chabriat, H.4 aut |
| 700 | 1 | a Hernandez, K.4 aut |
| 700 | 1 | a Kurtz, A.4 aut |
| 700 | 1 | a Herveacute, D.4 aut |
| 700 | 1 | a Benisty, S.4 aut |
| 700 | 1 | a Guichard, J. P.4 aut |
| 700 | 1 | a Baezner, H.4 aut |
| 700 | 1 | a Wiarda, M.4 aut |
| 700 | 1 | a Seip, S.4 aut |
| 700 | 1 | a Rostrup, E.4 aut |
| 700 | 1 | a Ryberg, C.4 aut |
| 700 | 1 | a Dyrby, T.4 aut |
| 700 | 1 | a Paulson, O. B.4 aut |
| 700 | 1 | a Frederiksen, K. S.4 aut |
| 700 | 1 | a O'Brien, J.4 aut |
| 700 | 1 | a Pakrasi, S.4 aut |
| 700 | 1 | a Krishnan, M.4 aut |
| 700 | 1 | a Teodorczuk, A.4 aut |
| 700 | 1 | a Firbank, M.4 aut |
| 700 | 1 | a Minett, T.4 aut |
| 700 | 1 | a Inzitari, D.4 aut |
| 700 | 1 | a Bartolini, L.4 aut |
| 700 | 1 | a Basile, A. M.4 aut |
| 700 | 1 | a Magnani, E.4 aut |
| 700 | 1 | a Martini, M.4 aut |
| 700 | 1 | a Mascalchi, M.4 aut |
| 700 | 1 | a Moretti, M.4 aut |
| 700 | 1 | a Pantoni, L.4 aut |
| 700 | 1 | a Poggesi, A.4 aut |
| 700 | 1 | a Pracucci, G.4 aut |
| 700 | 1 | a Salvadori, E.4 aut |
| 700 | 1 | a Simoni, M.4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t The American journal of geriatric psychiatryd : Elsevier BVg 23:1, s. 59-+q 23:1x 1064-7481 |
| 773 | 0 | t The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatryd : Elsevier BVg 23:1, s. 59-+q 23:1<59-+x 1545-7214 |
| 856 | 4 | u https://europepmc.org/articles/pmc4234689?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/226736 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jagp.2013.04.011 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130265253 |
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- Crisby, M.
- Örndahl, E.
- Erkinjuntti, T.
- Waldemar, G.
- Garde, E.
- Hennerici, M. G.
- Bäzner, H.
- Blahak, C.
- Wallin, Anders, ...
- Wahlund, L. O.
- Pohjasvaara, T.
- Pihanen, P.
- Ylikoski, R.
- Jokinen, H.
- Somerkoski, M. M ...
- Mäntylä, R.
- Salonen, O.
- Fazekas, F.
- Schmidt, R.
- Ropele, S.
- Rous, B.
- Petrovic, K.
- Garmehi, U.
- Seewann, A.
- Ferro, J. M.
- Verdelho, A.
- Madureira, S.
- Moleiro, C.
- Scheltens, P.
- Van Straaten, I.
- Barkhof, F.
- Gouw, A.
- van der Flier, W ...
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- Lind, K.
- Nordlund, A.
- Rolstad, S.
- Isblad, I.
- Pettersson, A.
- Amberla, K.
- Chabriat, H.
- Hernandez, K.
- Kurtz, A.
- Herveacute, D.
- Benisty, S.
- Guichard, J. P.
- Baezner, H.
- Wiarda, M.
- Seip, S.
- Rostrup, E.
- Ryberg, C.
- Dyrby, T.
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- Inzitari, D.
- Bartolini, L.
- Basile, A. M.
- Magnani, E.
- Martini, M.
- Mascalchi, M.
- Moretti, M.
- Pantoni, L.
- Poggesi, A.
- Pracucci, G.
- Salvadori, E.
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