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A tactile resonance...
A tactile resonance sensor for prostate cancer detection – evaluation on human prostate tissue
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- Lindahl, Olof A (författare)
- Umeå universitet,Centrum för medicinsk teknik och fysik (CMTF),Radiofysik,Radiation Sciences, Umeå Universitet Medicinska fakulteten, Department of Radiation Sciences, Radiation Physics/Biomedical Engineering, Umeå, 901 87, SWEDEN
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- Bäcklund, Tomas (författare)
- Umeå universitet,Institutionen för tillämpad fysik och elektronik,Radiofysik,Biomedical Engineering, Umeå University Department of Radiation Sciences, Department of Radiation Sciences, Radiation Physics/Biomedical Engineering, Umeå, 901 87, SWEDEN
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- Ramser, Kerstin (författare)
- Luleå tekniska universitet,Strömningslära och experimentell mekanik,Department of Engineering Sciences and Mathematics, Lulea University of Technology, Lulea, Sweden
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- Liv, Per, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå Universitet Medicinska fakulteten, Public Health and Clinical Medicine, Section of Sustainable health, Umeå, 90185, SWEDEN
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- Ljungberg, Börje, Professor, 1949- (författare)
- Umeå universitet,Urologi och andrologi,Umeå Universitet Medicinska fakulteten, Surgical and Perioperative sciences, Urology and Andrology, Umeå, 901 85, SWEDEN
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- Bergh, Anders (författare)
- Umeå universitet,Patologi,Umeå Universitet Medicinska fakulteten, Medical Bioscience, Pathology, Umeå, 90185, SWEDEN
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(creator_code:org_t)
- 2021-02-23
- 2021
- Engelska.
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Ingår i: Biomedical Engineering & Physics Express. - : Institute of Physics (IOP). - 2057-1976. ; 7:2
- Relaterad länk:
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https://doi.org/10.1...
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http://umu.diva-port...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Prostate cancer surgery risks erectile problems and incontinence for the patient. An instrument for guiding surgeons to avoid nerve bundle damage and ensure complete cancer removal is desirable. We present a tactile resonance sensor made of PZT ceramics, mounted in a 3D motorized translation stage for scanning and measuring tissue stiffness for detecting cancer in human prostate. The sensor may be used during surgery for guidance, scanning the prostate surface for the presence of cancer, indicating migration of cancer cells into surrounding tissue. Ten fresh prostates, obtained from patients undergoing prostate cancer surgery, were cut into 0.5 cm thick slices. Each slice was measured for tissue stiffness at about 25 different sites and compared to histology for validation cancer prediction by stiffness. The statistical analysis was based on a total of 148 sites with non-cancer and 40 sites with cancer. Using a generalized linear mixed model (GLMM), the stiffness data predicted cancer with an area under the curve of 0.74, after correcting for overfitting using bootstrap validation. Mean prostate stiffness on the logarithmic scale (p = 0.015) and standardized Z-scores (p = 0.025) were both significant predictors of cancer. This study concludes that stiffness measured by the tactile resonance sensor is a significant predictor of prostate cancer with potential for future development towards a clinical instrument for surgical guidance.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Teknisk mekanik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Applied Mechanics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Nyckelord
- Prostate cancer
- resonance sensor
- stiffness
- Experimentell mekanik
- Experimental Mechanics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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