Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury

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Jones, IwanUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Institutionen för integrativ medicinsk biologi (IMB) (author)

Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury

Article/chapterEnglish2018

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2018-02-18
Hindawi Limited,2018
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-147466
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147466URI
https://doi.org/10.1002/term.2642DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations, and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts is biodegradable conduits and transplanted cells that provide trophic support during the regenerative process. Neural crest cells are promising support cell candidates because they are the parent population to many peripheral nervous system lineages. In this study, neural crest cells were differentiated from human embryonic stem cells. The differentiated cells exhibited typical stellate morphology and protein expression signatures that were comparable with native neural crest. Conditioned media harvested from the differentiated cells contained a range of biologically active trophic factors and was able to stimulate in vitro neurite outgrowth. Differentiated neural crest cells were seeded into a biodegradable nerve conduit, and their regeneration potential was assessed in a rat sciatic nerve injury model. A robust regeneration front was observed across the entire width of the conduit seeded with the differentiated neural crest cells. Moreover, the up-regulation of several regeneration-related genes was observed within the dorsal root ganglion and spinal cord segments harvested from transplanted animals. Our results demonstrate that the differentiated neural crest cells are biologically active and provide trophic support to stimulate peripheral nerve regeneration. Differentiated neural crest cells are therefore promising supporting cell candidates to aid in peripheral nerve repair.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
artificial nerve graft
human embryonic stem cells
neural crest cells
peripheral nerve injuries
ripheral nervous system
VELOPMENTAL EVOLUTION
V314B
P95 e Gabsang
2007
NATURE BIOTECHNOLOGY
V25
P1468

Added entries (persons, corporate bodies, meetings, titles ...)

Novikova, Liudmila N.Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)luno0001 (author)
Novikov, Lev N.Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)leno0001 (author)
Renardy, Monika (author)
Ullrich, Andreas (author)
Wiberg, MikaelUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)miwi0004 (author)
Carlsson, LeifUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)leca0002 (author)
Kingham, Paul J.Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)paki0006 (author)
Umeå universitetUmeå centrum för molekylär medicin (UCMM) (creator_code:org_t)

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In:Journal of Tissue Engineering and Regenerative Medicine: Hindawi Limited12:4, s. E2099-E21091932-62541932-7005

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By the author/editor: Jones, Iwan; Novikova, Liudmi ...; Novikov, Lev N.; Renardy, Monika; Ullrich, Andreas; Wiberg, Mikael; show more...; Carlsson, Leif; Kingham, Paul J.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Journal of Tissu ...

By the university: Umeå University

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