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Biomarkers associat...
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Södergren, Anna,1977-Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
(författare)
Biomarkers associated with cardiovascular disease in patients with early rheumatoid arthritis
- Artikel/kapitelEngelska2019
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2019-08-05
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Public Library of Science,2019
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-164650
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164650URI
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https://doi.org/10.1371/journal.pone.0220531DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Objectives: Patients with rheumatoid arthritis (RA) have an increased mortality and morbidity due to cardiovascular disease (CVD). In this prospective 5-year follow up of patients with RA, we analysed several biomarkers, known to be associated with atherosclerosis and/or inflammation in the general population. The aim of this study was to find out whether the RA-disease per se affect these biomarkers and if those could be associated with the progression of atherosclerosis, as measured by intima media thickness (IMT) among patients with early RA.Methods: Patients from northern Sweden diagnosed with early RA, are consecutively recruited into an ongoing prospective study on CVD comorbidity. A subgroup of patients, aged ≤60 years (n = 71) was included for ultrasound measurements of IMT at inclusion (T0) and after 5 years (T5) together with age-sex-matched controls (n = 40). The patients were clinically assessed. Blood was analysed for lipids, ESR and CRP and several biomarkers known to be associated with atherosclerosis in the general population.Results: At T0, the patients with RA had significantly lower levels of MIF and significantly higher levels of interleukin (IL)-18 and MIC-1 compared with controls. At T5, the patients with RA had significantly higher levels of pentraxin3, MIC-1, TNF-R2, ICAM-1, VCAM-1 and endostatin compared with controls. At T0 the levels of MPO correlated with DAS28, sCD40L with CRP and IL-18 with systolic blood pressure and Reynolds risk score. Using PLSR on a CVD-panel analysed with multiplex immunoassay, the patients with RA could be correctly classified into those who had a worsening in their IMT over the five years or not. Here, MMP3 was identified as influential.Conclusions: This study indicates that the RA disease itself could affect several of the biomarkers in this study, and possibly also the processes involved in the development of atherosclerosis.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Karp, KjellUmeå universitet,Klinisk fysiologi(Swepub:umu)kjka0001
(författare)
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Bengtsson, ChristineUmeå universitet,Reumatologi,Department of Rheumatology, Kristianstad Hospital, Kristianstad, Sweden(Swepub:umu)chbe0055
(författare)
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Möller, Bozena
(författare)
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Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi(Swepub:umu)sora0001
(författare)
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Wållberg-Jonsson, Solveig,1953-Umeå universitet,Reumatologi(Swepub:umu)sowa0001
(författare)
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Umeå universitetReumatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PLOS ONE: Public Library of Science14:81932-6203
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