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Connecting Inflamma...
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Erhardt, SophieKarolinska Institutet,Karolinska Institute, Sweden
(author)
Connecting Inflammation with Glutamate Agonism in Suicidality
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-12-03
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Nature Publishing Group: Open Access Hybrid Model Option A,2013
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-91010
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91010URI
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https://doi.org/10.1038/npp.2012.248DOI
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https://lup.lub.lu.se/record/3636081URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126382222URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council|2009-42842011-47872002-52972008-29222009-70522011-4795|Province of Scania clinical state grants (ALF)||American Foundation for Suicide Prevention|2-DIG-00030-0608-1208|Rebecca Cooper Foundation||National Health Medical Research Council in Australia (NHMRC)||
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The NMDA-receptor antagonist ketamine has proven efficient in reducing symptoms of suicidality, although the mechanisms explaining this effect have not been detailed in psychiatric patients. Recent evidence points towards a low-grade inflammation in brains of suicide victims. Inflammation leads to production of quinolinic acid (QUIN) and kynurenic acid (KYNA), an agonist and antagonist of the glutamatergic N-methyl-D-aspartate (NMDA) receptor, respectively. We here measured QUIN and KYNA in the cerebrospinal fluid (CSF) of 64 medication-free suicide attempters and 36 controls, using gas chromatography mass spectrometry and high-performance liquid chromatography. We assessed the patients clinically using the Suicide Intent Scale and the Montgomery Asberg Depression Rating Scale (MADRS). We found that QUIN, but not KYNA, was significantly elevated in the CSF of suicide attempters (Pandlt;0.001). As predicted, the increase in QUIN was associated with higher levels of CSF interleukin-6. Moreover, QUIN levels correlated with the total scores on Suicide Intent Scale. There was a significant decrease of QUIN in patients who came for follow-up lumbar punctures within 6 months after the suicide attempt. In summary, we here present clinical evidence of increased QUIN in the CSF of suicide attempters. An increased QUIN/KYNA quotient speaks in favor of an overall NMDA-receptor stimulation. The correlation between QUIN and the Suicide Intent Scale indicates that changes in glutamatergic neurotransmission could be specifically linked to suicidality. Our findings have important implications for the detection and specific treatment of suicidal patients, and might explain the observed remedial effects of ketamine. Neuropsychopharmacology (2013) 38, 743-752; doi:10.1038/npp.2012.248; published online 9 January 2013
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lim, Chai K.University of New S Wales, Australia
(author)
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Linderholm, Klas R.Karolinska Institute, Sweden
(author)
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Janelidze, ShorenaLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)nkir-sje
(author)
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Lindqvist, DanielLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)med-del
(author)
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Samuelsson, MartinÖstergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken(Swepub:liu)marsa78
(author)
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Lundberg, KristinaLinköpings universitet,Psykiatri,Hälsouniversitetet
(author)
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Postolache, Teodor TUniversity of Maryland, MD USA
(author)
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Träskman Bendz, LilLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)psyk-lt8
(author)
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Guillemin, Gilles JUniversity of New S Wales, Australia
(author)
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Brundin, LenaLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)mphy-lla
(author)
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Karolinska InstitutetKarolinska Institute, Sweden
(creator_code:org_t)
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In:Neuropsychopharmacology: Nature Publishing Group: Open Access Hybrid Model Option A38:5, s. 743-7520893-133X1740-634X
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