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FältnamnIndikatorerMetadata
00004634naa a2200649 4500
001oai:DiVA.org:uu-216720
003SwePub
008140124s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2167202 URI
0247 a https://doi.org/10.1038/nature127362 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Raghavan, Maanasa4 aut
2451 0a Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans
264 c 2013-11-20
264 1b Springer Science and Business Media LLC,c 2014
338 a print2 rdacarrier
500 a De två (2) första författarna delar förstaförfattarskapet.
520 a The origins of the First Americans remain contentious. Although Native Americans seem to be genetically most closely related to east Asians(1-3), there is no consensus with regard to which specific Old World populations they are closest to(4-8). Here we sequence the draft genome of an approximately 24,000-year-old individual (MA-1), from Mal'ta in south-central Siberia(9), to an average depth of 1x. To our knowledge this is the oldest anatomically modern human genome reported to date. The MA-1 mitochondrial genome belongs to haplogroup U, which has also been found at high frequency among Upper Palaeolithic and Mesolithic European hunter-gatherers(10-12), and the Y chromosome of MA-1 is basal to modern-day western Eurasians and near the root of most Native American lineages(5). Similarly, we find autosomal evidence that MA-1 is basal to modern-day western Eurasians and genetically closely related to modern-day Native Americans, with no close affinity to east Asians. This suggests that populations related to contemporary western Eurasians had a more north-easterly distribution 24,000 years ago than commonly thought. Furthermore, we estimate that 14 to 38% of Native American ancestry may originate through gene flow from this ancient population. This is likely to have occurred after the divergence of Native American ancestors from east Asian ancestors, but before the diversification of Native American populations in the New World. Gene flow from the MA-1 lineage into Native American ancestors could explain why several crania from the First Americans have been reported as bearing morphological characteristics that do not resemble those of east Asians(2,13). Sequencing of another south-central Siberian, Afontova Gora-2 dating to approximately 17,000 years ago(14), revealed similar autosomal genetic signatures as MA-1, suggesting that the region was continuously occupied by humans throughout the Last Glacial Maximum. Our findings reveal that western Eurasian genetic signatures in modern-day Native Americans derive not only from post-Columbian admixture, as commonly thought, but also from a mixed ancestry of the First Americans.
7001 a Skoglund, Pontusu Uppsala universitet,Evolutionsbiologi4 aut0 (Swepub:uu)ponsk973
7001 a Graf, Kelly E.4 aut
7001 a Metspalu, Mait4 aut
7001 a Albrechtsen, Anders4 aut
7001 a Moltke, Ida4 aut
7001 a Rasmussen, Simon4 aut
7001 a Stafford, Thomas W., Jr.4 aut
7001 a Orlando, Ludovic4 aut
7001 a Metspalu, Ene4 aut
7001 a Karmin, Monika4 aut
7001 a Tambets, Kristiina4 aut
7001 a Rootsi, Siiri4 aut
7001 a Maegi, Reedik4 aut
7001 a Campos, Paula F.4 aut
7001 a Balanovska, Elena4 aut
7001 a Balanovsky, Oleg4 aut
7001 a Khusnutdinova, Elza4 aut
7001 a Litvinov, Sergey4 aut
7001 a Osipova, Ludmila P.4 aut
7001 a Fedorova, Sardana A.4 aut
7001 a Voevoda, Mikhail I.4 aut
7001 a DeGiorgio, Michael4 aut
7001 a Sicheritz-Ponten, Thomas4 aut
7001 a Brunak, Soren4 aut
7001 a Demeshchenko, Svetlana4 aut
7001 a Kivisild, Toomas4 aut
7001 a Villems, Richard4 aut
7001 a Nielsen, Rasmus4 aut
7001 a Jakobsson, Mattiasu Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)matja323
7001 a Willerslev, Eske4 aut
7102 a Uppsala universitetb Evolutionsbiologi4 org
7730 t Natured : Springer Science and Business Media LLCg 505:7481, s. 87-+q 505:7481<87-+x 0028-0836x 1476-4687
8564 u https://europepmc.org/articles/pmc4105016?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216720
8564 8u https://doi.org/10.1038/nature12736

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