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Effects of Teripara...
Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture Results of a Randomized, Active-Controlled, Double-Blind Clinical Trial at 26 Weeks
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- Aspenberg, Per (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Ortopedkliniken i Linköping
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- Malouf, Jorge (författare)
- Hospital San Pablo, Spain
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- Tarantino, Umberto (författare)
- University of Roma Tor Vergata, Italy
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- Garcia-Hernandez, Pedro A. (författare)
- University Hospital, Mexico
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- Corradini, Costantino (författare)
- University of Milan, Italy
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- Overgaard, Soren (författare)
- Odense University Hospital, Denmark; University of Southern Denmark, Denmark
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- Stepan, Jan J. (författare)
- Charles University of Prague, Czech Republic; Charles University of Prague, Czech Republic
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- Borris, Lars (författare)
- University Hospital, Denmark
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- Lespessailles, Eric (författare)
- CHR Orleans, France; University of Orleans, France
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- Frihagen, Frede (författare)
- Oslo University Hospital, Norway
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- Papavasiliou, Kyriakos (författare)
- Aristotle University of Thessaloniki, Greece
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- Petto, Helmut (författare)
- Eli Lilly, Austria
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- Ramon Caeiro, Jose (författare)
- University of Santiago de Compostela, Spain
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- Marin, Fernando (författare)
- Eli Lilly Research Centre, England
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(creator_code:org_t)
- JOURNAL BONE JOINT SURGERY, 2016
- 2016
- Engelska.
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Ingår i: Journal of Bone and Joint Surgery. American volume. - : JOURNAL BONE JOINT SURGERY. - 0021-9355 .- 1535-1386. ; 98:22
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background: Osteoporosis drugs might affect fracture-healing. We therefore studied the effects of teriparatide in comparison with risedronate on recovery after pertrochanteric hip fractures. Methods: The study was a randomized, multicenter, active-controlled, 78-week trial comparing teriparatide (20 mg/day) with risedronate (35 mg/week) initiated within 2 weeks after fixation of a low-trauma pertrochanteric hip fracture (AO/OTA 31-A1 or 31-A2). The main inclusion criteria were a bone mineral density T-score of amp;lt;=-22.0 and 25-OH-vitamin D of amp;gt;= 9.2 ng/mL. During the first 26 weeks, patients received study medication with oral or injectable placebo plus calcium and vitamin D in a double-blinded fashion. Secondary (Timed Up-and-Go [TUG] test, hip pain, Short Form [SF]-36 health status, and safety) and exploratory (radiographic outcomes and ability to walk) 26-week end points are reported. Results: Of the 224 patients who were randomized, 171 (86 teriparatide, 85 risedronate) were included in the analysis. The mean age was 77 +/- 8 years, 77% were female, and 26% had a prior history of low-trauma fracture. The teriparatide group completed the TUG test in a shorter time at 6, 12, 18, and 26 weeks (differences of 25.7, -4.4, -3.1, and -3.1 seconds, respectively; p = 0.021 for the overall difference). They also reported less pain on a visual analog scale immediately after the TUG test at 12 and 18 weeks (adjusted absolute differences of 10.6 and 11.9 mm, respectively; p amp;lt; 0.05). There were no significant between-group differences in the SF-36 score, Charnley hip pain score, ability to walk, or use of walking aids during follow-up. Radiographic healing at 6, 12, and 26 weeks, mechanical failure of the implant (teriparatide, 7; risedronate, 8), loss of reduction (teriparatide, 2; risedronate, 4), and nonunion (0 cases) were not significantly different. Mild hypercalcemia and hyperuricemia were more frequent with teriparatide. Conclusions: Teriparatide was associated with less pain and a shorter time to complete the TUG test between 6 and 26 weeks compared with risedronate. Other fracture-recovery outcomes were similar. The results should be interpreted with caution as these were secondary end points.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
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Aspenberg, Per
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Malouf, Jorge
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Tarantino, Umber ...
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Garcia-Hernandez ...
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Corradini, Costa ...
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Overgaard, Soren
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Stepan, Jan J.
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Borris, Lars
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Lespessailles, E ...
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Frihagen, Frede
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Papavasiliou, Ky ...
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Petto, Helmut
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Ramon Caeiro, Jo ...
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Marin, Fernando
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Linköpings universitet