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Sökning: WFRF:(TARANTINO A) > Effects of Teripara...

  • Aspenberg, PerLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Ortopedkliniken i Linköping (författare)

Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture Results of a Randomized, Active-Controlled, Double-Blind Clinical Trial at 26 Weeks

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • JOURNAL BONE JOINT SURGERY,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-136235
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136235URI
  • https://doi.org/10.2106/JBJS.15.01217DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Eli Lilly
  • Background: Osteoporosis drugs might affect fracture-healing. We therefore studied the effects of teriparatide in comparison with risedronate on recovery after pertrochanteric hip fractures. Methods: The study was a randomized, multicenter, active-controlled, 78-week trial comparing teriparatide (20 mg/day) with risedronate (35 mg/week) initiated within 2 weeks after fixation of a low-trauma pertrochanteric hip fracture (AO/OTA 31-A1 or 31-A2). The main inclusion criteria were a bone mineral density T-score of amp;lt;=-22.0 and 25-OH-vitamin D of amp;gt;= 9.2 ng/mL. During the first 26 weeks, patients received study medication with oral or injectable placebo plus calcium and vitamin D in a double-blinded fashion. Secondary (Timed Up-and-Go [TUG] test, hip pain, Short Form [SF]-36 health status, and safety) and exploratory (radiographic outcomes and ability to walk) 26-week end points are reported. Results: Of the 224 patients who were randomized, 171 (86 teriparatide, 85 risedronate) were included in the analysis. The mean age was 77 +/- 8 years, 77% were female, and 26% had a prior history of low-trauma fracture. The teriparatide group completed the TUG test in a shorter time at 6, 12, 18, and 26 weeks (differences of 25.7, -4.4, -3.1, and -3.1 seconds, respectively; p = 0.021 for the overall difference). They also reported less pain on a visual analog scale immediately after the TUG test at 12 and 18 weeks (adjusted absolute differences of 10.6 and 11.9 mm, respectively; p amp;lt; 0.05). There were no significant between-group differences in the SF-36 score, Charnley hip pain score, ability to walk, or use of walking aids during follow-up. Radiographic healing at 6, 12, and 26 weeks, mechanical failure of the implant (teriparatide, 7; risedronate, 8), loss of reduction (teriparatide, 2; risedronate, 4), and nonunion (0 cases) were not significantly different. Mild hypercalcemia and hyperuricemia were more frequent with teriparatide. Conclusions: Teriparatide was associated with less pain and a shorter time to complete the TUG test between 6 and 26 weeks compared with risedronate. Other fracture-recovery outcomes were similar. The results should be interpreted with caution as these were secondary end points.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Malouf, JorgeHospital San Pablo, Spain (författare)
  • Tarantino, UmbertoUniversity of Roma Tor Vergata, Italy (författare)
  • Garcia-Hernandez, Pedro A.University Hospital, Mexico (författare)
  • Corradini, CostantinoUniversity of Milan, Italy (författare)
  • Overgaard, SorenOdense University Hospital, Denmark; University of Southern Denmark, Denmark (författare)
  • Stepan, Jan J.Charles University of Prague, Czech Republic; Charles University of Prague, Czech Republic (författare)
  • Borris, LarsUniversity Hospital, Denmark (författare)
  • Lespessailles, EricCHR Orleans, France; University of Orleans, France (författare)
  • Frihagen, FredeOslo University Hospital, Norway (författare)
  • Papavasiliou, KyriakosAristotle University of Thessaloniki, Greece (författare)
  • Petto, HelmutEli Lilly, Austria (författare)
  • Ramon Caeiro, JoseUniversity of Santiago de Compostela, Spain (författare)
  • Marin, FernandoEli Lilly Research Centre, England (författare)
  • Linköpings universitetAvdelningen för kliniska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Bone and Joint Surgery. American volume: JOURNAL BONE JOINT SURGERY98:220021-93551535-1386

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