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Current state of Al...
Current state of Alzheimer's fluid biomarkers
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Molinuevo, J. L. (author)
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Ayton, S. (author)
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Batrla, R. (author)
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Bednar, M. M. (author)
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Bittner, T. (author)
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Cummings, J. (author)
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Fagan, A. M. (author)
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Hampel, H. (author)
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Mielke, M. M. (author)
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Mikulskis, A. (author)
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O'Bryant, S. (author)
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Scheltens, P. (author)
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Sevigny, J. (author)
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Shaw, L. M. (author)
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Soares, H. D. (author)
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Tong, G. (author)
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Trojanowski, J. Q. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2018-11-28
- 2018
- English.
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In: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 136:6, s. 821-853
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is predicted to increase; however, there are no disease-modifying therapies currently available and none have been successful in late-stage clinical trials. Fluid biomarkers measured in cerebrospinal fluid (CSF) or blood hold promise for enabling more effective drug development and establishing a more personalized medicine approach for AD diagnosis and treatment. Biomarkers used in drug development programmes should be qualified for a specific context of use (COU). These COUs include, but are not limited to, subject/patient selection, assessment of disease state and/or prognosis, assessment of mechanism of action, dose optimization, drug response monitoring, efficacy maximization, and toxicity/adverse reactions identification and minimization. The core AD CSF biomarkers A42, t-tau, and p-tau are recognized by research guidelines for their diagnostic utility and are being considered for qualification for subject selection in clinical trials. However, there is a need to better understand their potential for other COUs, as well as identify additional fluid biomarkers reflecting other aspects of AD pathophysiology. Several novel fluid biomarkers have been proposed, but their role in AD pathology and their use as AD biomarkers have yet to be validated. In this review, we summarize some of the pathological mechanisms implicated in the sporadic AD and highlight the data for several established and novel fluid biomarkers (including BACE1, TREM2, YKL-40, IP-10, neurogranin, SNAP-25, synaptotagmin, -synuclein, TDP-43, ferritin, VILIP-1, and NF-L) associated with each mechanism. We discuss the potential COUs for each biomarker.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid
- Biomarker
- Blood
- Cerebrospinal fluid
- Tau
- mild cognitive impairment
- visinin-like protein-1
- neurofilament
- light-chain
- amyloid precursor protein
- alpha-synuclein levels
- frontotemporal lobar degeneration
- creutzfeldt-jakob-disease
- blood-based biomarkers
- acid-binding protein
- a-beta peptides
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To the university's database
- By the author/editor
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Molinuevo, J. L.
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Ayton, S.
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Batrla, R.
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Bednar, M. M.
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Bittner, T.
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Cummings, J.
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show more...
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Fagan, A. M.
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Hampel, H.
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Mielke, M. M.
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Mikulskis, A.
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O'Bryant, S.
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Scheltens, P.
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Sevigny, J.
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Shaw, L. M.
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Soares, H. D.
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Tong, G.
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Trojanowski, J. ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Acta Neuropathol ...
- By the university
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University of Gothenburg