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AA-amyloidosis. Tis...
AA-amyloidosis. Tissue component-specific association of various protein AA subspecies and evidence of a fourth SAA gene product
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- Westermark, Gunilla T. (författare)
- Linköping University
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- Sletten, Knut (författare)
- Lund University
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- Grubb, Anders (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups
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- Westermark, Per (författare)
- University of Oslo
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(creator_code:org_t)
- 1990
- 1990
- Engelska 7 s.
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Ingår i: American Journal of Pathology. - 0002-9440. ; 137:2, s. 377-383
- Relaterad länk:
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https://www.ncbi.nlm... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Protein AA, the major repetitive protein subunit present in fibrils deposited in AA-amyloidosis, is an N-terminal cleavage product of a 104-amino acid precursor, serum amyloid A (SAA). Protein AA subspecies varying between 45 and 94 amino acids in length have been described. In this study it is shown that the different protein AA subspecies are not evenly distributed in amyloid deposits and that in single patients, certain subspecies of protein AA are deposited in specific tissue component sites. Thus larger protein AA subspecies occur in lower concentration in amyloid in the glomeruli compared to other sites and are especially found in amyloid in vessel walls. Three different SAA forms have been predicted from genomic and complementary DNA studies. The existence of a fourth type has been suspected from amino acid sequence studies of purified SAA. Protein AA derived from this fourth type of SAA is now shown to be present in amyloid fibrils in one of the patients studied in this paper.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Amino Acid Sequence
- Amyloidosis/metabolism
- Blotting, Western
- Chromatography, High Pressure Liquid
- Electrophoresis, Polyacrylamide Gel
- Humans
- Immune Sera/immunology
- Immunohistochemistry
- Kidney/metabolism
- Molecular Sequence Data
- Serum Amyloid A Protein/genetics
- Spleen/metabolism
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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