Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix

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Search: AMNE:(MEDICAL AND HEALTH SCIENCES) AMNE:(Medical Biotechnology) AMNE:(Biomaterials Science) > Biomaterial Integra...

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Fältnamn	Indikatorer	Metadata
000		04589naa a2200517 4500
001		oai:research.chalmers.se:1151215d-30a5-4758-afa0-d487ef2e21d3
003		SwePub
008		220507s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:gup.ub.gu.se/316453
024	7	a https://research.chalmers.se/publication/5302332 URI
024	7	a https://doi.org/10.1002/mabi.2022000372 DOI
024	7	a https://gup.ub.gu.se/publication/3164532 URI
040		a (SwePub)cthd (SwePub)gu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a von Mentzer, Ula,d 1995u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)peiciute
245	1 0	a Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix
264		c 2022-04-27
264	1	b Wiley,c 2022
338		a electronic2 rdacarrier
520		a Defects of articular joints are becoming an increasing societal burden due to a persistent increase in obesity and aging. For some patients suffering from cartilage erosion, joint replacement is the final option to regain proper motion and limit pain. Extensive research has been undertaken to identify novel strategies enabling earlier intervention to promote regeneration and cartilage healing. With the introduction of decellularized extracellular matrix (dECM), researchers have tapped into the potential for increased tissue regeneration by designing biomaterials with inherent biochemical and immunomodulatory signals. Compared to conventional and synthetic materials, dECM-based materials invoke a reduced foreign body response. It is therefore highly beneficial to understand the interplay of how these native tissue-based materials initiate a favorable remodeling process by the immune system. Yet, such an understanding also demands increasing considerations of the pathological environment and remodeling processes, especially for materials designed for early disease intervention. This knowledge will avoid rejection and help predict complications in conditions with inflammatory components such as arthritides. This review outlines general issues facing biomaterial integration and emphasizes the importance of tissue-derived macromolecular components in regulating essential homeostatic, immunological, and pathological processes to increase biomaterial integration for patients suffering from joint degenerative diseases.
650	7	a TEKNIK OCH TEKNOLOGIERx Maskinteknikx Produktionsteknik, arbetsvetenskap och ergonomi0 (SwePub)203072 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Mechanical Engineeringx Production Engineering, Human Work Science and Ergonomics0 (SwePub)203072 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Annan teknikx Övrig annan teknik0 (SwePub)211992 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Other Engineering and Technologiesx Other Engineering and Technologies not elsewhere specified0 (SwePub)211992 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Industriell bioteknikx Medicinsk bioteknik0 (SwePub)209082 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Industrial Biotechnologyx Medical Biotechnology0 (SwePub)209082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
653		a rheumatoid arthritis
653		a immune systems
653		a osteoarthritis
653		a cartilage
653		a extracellular matrix
653		a biomaterials
653		a implants
700	1	a Corciulo, Carmenu Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xcorca
700	1	a Stubelius, Alexandra,d 1983u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)karlstra
710	2	a Chalmers tekniska högskolab Centre for Bone and Arthritis Research4 org
773	0	t Macromolecular Bioscienced : Wileyg 22:7q 22:7x 1616-5195x 1616-5187
856	4	u https://research.chalmers.se/publication/530233/file/530233_Fulltext.pdfx primaryx freey FULLTEXT
856	4 8	u https://research.chalmers.se/publication/530233
856	4 8	u https://doi.org/10.1002/mabi.202200037
856	4 8	u https://gup.ub.gu.se/publication/316453

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