Perturbation-evoked responses in primary motor cortex are modulated by behavioral context

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Fältnamn	Indikatorer	Metadata
000		04127naa a2200445 4500
001		oai:DiVA.org:umu-97891
003		SwePub
008		150108s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-978912 URI
024	7	a https://doi.org/10.1152/jn.00270.20142 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Omrani, Mohsenu Center for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada4 aut
245	1 0	a Perturbation-evoked responses in primary motor cortex are modulated by behavioral context
264	1	b American Physiological Society,c 2014
338		a print2 rdacarrier
520		a Corrective responses to external perturbations are sensitive to the behavioral task being performed. It is believed that primary motor cortex (M1) forms part of a transcortical pathway that contributes to this sensitivity. Previous work has identified two distinct phases in the perturbation response of M1 neurons, an initial response starting similar to 20 ms after perturbation onset that does not depend on the intended motor action and a task- dependent response that begins similar to 40 ms after perturbation onset. However, this invariant initial response may reflect ongoing postural control or a task- independent response to the perturbation. The present study tested these two possibilities by examining if being engaged in an ongoing postural task before perturbation onset modulated the initial perturbation response in M1. Specifically, mechanical perturbations were applied to the shoulder and/ or elbow while the monkey maintained its hand at a central target or when it was watching a movie and not required to respond to the perturbation. As expected, corrective movements, muscle stretch responses, and M1 population activity in the late perturbation epoch were all significantly diminished in the movie task. Strikingly, initial perturbation responses (<40 ms postperturbation) remained the same across tasks, suggesting that the initial phase of M1 activity constitutes a task- independent response that is sensitive to the properties of the mechanical perturbation but not the goal of the ongoing motor task.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653		a feedback control
653		a task dependency
653		a transcortical feedback pathway
653		a reflex
653		a task-independent sponse
653		a neural activity
653		a primary motor cortex
700	1	a Pruszynski, J. Andrewu Umeå universitet,Fysiologi,Center for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada4 aut0 (Swepub:umu)anpr0006
700	1	a Murnaghan, Chantelle D.u Center for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada4 aut
700	1	a Scott, Stephen H.u Center for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada ; Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada ; Department of Medicine Queen's University, Kingston, Ontario, Canada4 aut
710	2	a Center for Neuroscience Studies, Queen's University, Kingston, Ontario, Canadab Fysiologi4 org
773	0	t Journal of Neurophysiologyd : American Physiological Societyg 112:11, s. 2985-3000q 112:11<2985-3000x 0022-3077x 1522-1598
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97891
856	4 8	u https://doi.org/10.1152/jn.00270.2014

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Av författaren/redakt...: Omrani, Mohsen; Pruszynski, J. A ...; Murnaghan, Chant ...; Scott, Stephen H ...

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