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Celiac Disease Does...
Celiac Disease Does Not Influence Fracture Risk in Young Patients with Type 1 Diabetes
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- Reilly, Norelle R. (author)
- Division of Pediatric Gastroenterology, Columbia University Medical Center, New York NY, USA; Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA
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- Lebwohl, Benjamin (author)
- Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Mollazadegan, Kaziwe (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Michaëlsson, Karl, 1959- (author)
- Uppsala universitet,Ortopedi
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- Green, Peter H. R. (author)
- Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
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In: The Journal of Pediatrics. - : Elsevier. - 0022-3476 .- 1097-6833. ; 169, s. 49-54
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Abstract
Subject headings
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- Objectives: To examine the risk of any fractures in patients with both type 1 diabetes (T1D) and celiac disease (CD) vs patients with T1D only.Study design: We performed a population-based cohort study. We defined T1D as individuals aged <= 30 years who had a diagnosis of diabetes recorded in the Swedish National Patient Register between 1964 and 2009. Individuals with CD were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both T1D and CD and were matched for sex, age, and calendar period with 4598 reference individuals with T1D only. We then used a stratified Cox regression analysis, where CD was modeled as a time-dependent covariate, to estimate the risk of any fractures and osteoporotic fractures (hip, distal forearm, thoracic and lumbar spine, and proximal humerus) in patients with both T1D and CD compared with that in patients with T1D only.Results: During follow-up, 12 patients with T1D and CD had a fracture (1 osteoporotic fracture). CD did not influence the risk of any fracture (adjusted hazard ratio = 0.77; 95% CI = 0.42-1.41) or osteoporotic fractures (adjusted hazard ratio = 0.46; 95% CI = 0.06-3.51) in patients with T1D. Stratification for time since CD diagnosis did not affect risk estimates.Conclusion: Having a diagnosis of CD does not seem to influence fracture risk in young patients with T1D. Follow-up in this study was, however, too short to ascertain osteoporotic fractures which traditionally occur in old age.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Pediatrik
- Pediatrics
Publication and Content Type
- ref (subject category)
- art (subject category)
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