Efficacy of succimer chelation of mercury at background exposures in toddlers: a randomized trial

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Fältnamn	Indikatorer	Metadata
000		04229naa a2200385 4500
001		oai:DiVA.org:oru-66001
003		SwePub
008		201214s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-660012 URI
024	7	a https://doi.org/10.1016/j.jpeds.2010.08.0362 DOI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Cao, Yang,c Associate Professor,d 1972-u Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, China4 aut0 (Swepub:oru)yco
245	1 0	a Efficacy of succimer chelation of mercury at background exposures in toddlers :b a randomized trial
264	1	b Elsevier,c 2011
338		a print2 rdacarrier
520		a OBJECTIVE: To examine whether succimer, a mercaptan compound known to reduce blood lead concentration in children, reduces blood mercury concentration.STUDY DESIGN: We used samples from a randomized clinical trial of succimer chelation for lead-exposed children. We measured mercury levels in pre-treatment samples from 767 children. We also measured mercury levels in blood samples drawn 1 week after treatment began (n = 768) and in a 20% random sample of the children who received the maximum 3 courses of treatment (n = 67). A bootstrap-based isotonic regression method was used to compare the trend with time in the difference between the adjusted mean mercury concentrations in the succimer group and that in the placebo group.RESULTS: The adjusted mean organic mercury concentration in the succimer group relative to the placebo group fell from 99% at baseline to 82% after 3 courses of treatment (P for trend = .048), but this resulted from the prevention of the age-related increase in the succimer group.CONCLUSION: Succimer chelation for low level organic mercury exposure in children has limited efficacy.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
700	1	a Chen, Aiminu Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA4 aut
700	1	a Jones, Robert L.u Inorganic and Radiation Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA4 aut
700	1	a Radcliffe, Jerilynnu The Children’s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA, USA4 aut
700	1	a Dietrich, Kim N.u Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA4 aut
700	1	a Caldwell, Kathleen L.u Inorganic and Radiation Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA4 aut
700	1	a Peddada, Shyamalu Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, USA4 aut
700	1	a Rogan, Walter Ju Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA4 aut
710	2	a Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, Chinab Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA4 org
773	0	t The Journal of Pediatricsd : Elsevierg 158:3, s. 480-485.e1q 158:3<480-485.e1x 0022-3476x 1097-6833
856	4	u https://doi.org/10.1016/j.jpeds.2010.08.036y Fulltext
856	4	u https://europepmc.org/articles/pmc3086399?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66001
856	4 8	u https://doi.org/10.1016/j.jpeds.2010.08.036

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Av författaren/redakt...: Cao, Yang, Assoc ...; Chen, Aimin; Jones, Robert L.; Radcliffe, Jeril ...; Dietrich, Kim N.; Caldwell, Kathle ...; visa fler...; Peddada, Shyamal; Rogan, Walter J; visa färre...

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