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Safety and tolerabi...
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Busse, W. W.
(författare)
Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the beta(2) agonist vilanterol administered once daily for 52 weeks in patients >= 12 years old with asthma: a randomised trial
- Artikel/kapitelEngelska2013
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LIBRIS-ID:oai:gup.ub.gu.se/178755
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https://gup.ub.gu.se/publication/178755URI
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https://doi.org/10.1136/thoraxjnl-2012-202606DOI
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Ämneskategori:art swepub-publicationtype
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Background The inhaled corticosteroid fluticasone furoate (FF) in combination with the long-acting β2 agonist vilanterol (VI) is in development for asthma and chronic obstructive pulmonary disease. Objective To assess the safety and tolerability of FF/VI over 52weeks in patients with asthma. Methods Patients (aged ≥12years; on inhaled corticosteroid) were randomised (2:2:1) to FF/VI 100/25µg or FF/VI 200/25µg once daily in the evening, or fluticasone propionate (FP) 500µg twice daily. Safety evaluations included adverse events (AEs), non-fasting glucose, potassium, 24-h urinary cortisol excretion, ophthalmic assessments, heart rate and pulse rate. Results On-treatment AEs were similar across groups (FF/VI 66–69%; 73% FP). Oral candidiasis/oropharyngeal candidiasis was more common with FF/VI (6–7%) than FP (3%). Twelve serious AEs were reported; one (worsening hepatitis B on FP) was considered drug related. Statistically significant cortisol suppression was seen with FP compared with both FF/VI groups at Weeks 12 and 28 (ratios [95% CI] to FP ranged from 1.43 [1.11 to 1.84] to 1.67 [1.34 to 2.08]; p≤0.006), but not at Week 52 (ratios to FP were 1.05 [0.83 to 1.33] for FF/VI 100/25µg and 1.09 [0.87 to 1.38] for FF/VI 200/25µg). No clinically important changes in non-fasting glucose, potassium, QT interval corrected using Fridericia's formula (QTc[F]) or ophthalmic assessments were reported. Pulse rate (10min post dose [Tmax], Week 52) was significantly increased with FF/VI versus FP (3.4bpm, 95% CI 1.3 to 5.6; p=0.002 [FF/VI 100/25µg]; 3.4bpm, 95% CI 1.2 to 5.6; p=0.003 [FF/VI 200/25µg]). Mean heart rate (24-h Holter monitoring) decreased from screening values in all groups (0.2–1.1bpm FF/VI vs 5bpm FP; Week 52). Conclusions FF/VI (100/25µg or 200/25µg) administered once daily over 52weeks was well tolerated by patients aged ≥12years with asthma. The overall safety profile of FF/VI did not reveal any findings of significant clinical concern.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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O'Byrne, P. M.
(författare)
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Bleecker, E. R.
(författare)
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Lötvall, Jan,1956Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xlotja
(författare)
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Woodcock, A.
(författare)
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Andersen, L.
(författare)
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Hicks, W.
(författare)
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Crawford, J.
(författare)
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Jacques, L.
(författare)
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Apoux, L.
(författare)
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Bateman, E. D.
(författare)
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Göteborgs universitetKrefting Research Centre
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Thorax: BMJ68:6, s. 513-5200040-63761468-3296
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Thorax
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Busse, W. W.
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O'Byrne, P. M.
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Bleecker, E. R.
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Lötvall, Jan, 19 ...
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Woodcock, A.
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Andersen, L.
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visa fler...
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Hicks, W.
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Crawford, J.
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Jacques, L.
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Apoux, L.
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Bateman, E. D.
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Göteborgs universitet