L773:1879 0089 OR L773:0145 305X
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IgA deficiency in wolves
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- Frankowiack, Marcel (author)
- Karolinska Institutet
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- Hellman, Lars (author)
- Uppsala universitet,Kemisk biologi
- Zhao, Yaofeng (author)
- show more...
- Lin, Miaoli (author)
- Moller, Torsten (author)
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- (creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
- In: Developmental and Comparative Immunology. - : Elsevier BV. - 0145-305X .- 1879-0089. ; 40:2, s. 180-184
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Low mean concentrations of serum immunoglobulin A (IgA) and an increased frequency of overt IgA deficiency (IgAD) in certain dog breeds raises the question whether it is a breeding-enriched phenomenon or a legacy from the dog's ancestor, the gray wolf (Canis lupus). The IgA concentration in 99 serum samples from 58 free-ranging and 13 captive Scandinavian wolves, was therefore measured by capture ELISA. The concentrations were markedly lower in the wolf serum samples than in the dog controls. Potential differences in the IgA molecule between dogs and wolves were addressed by sequencing the wolf IgA heavy chain constant region encoding gene (IGHA). Complete amino acid sequence homology was found. Detection of wolf and dog IgA was ascertained by showing identity using double immunodiffusion. We suggest that the vast majority of wolves, the ancestor of the dog, are IgA deficient.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Annan veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Other Veterinary Science (hsv//eng)
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
Keyword
- Serum IgA concentrations
- IgA deficiency
- Dog
- Wolf
Publication and Content Type
- ref (subject category)
- art (subject category)
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- AGRICULTURAL SCIENCES
- AGRICULTURAL SCI ...
- and Veterinary Scien ...
- and Other Veterinary ...
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- NATURAL SCIENCES
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- and Ecology
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