Decreased Systemic Levels of Endocan-1 and CXCL16 in Psoriasis Are Restored following Narrowband UVB Treatment.

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Fältnamn	Indikatorer	Metadata
000		04318naa a2200409 4500
001		oai:DiVA.org:liu-151989
003		SwePub
008		181012s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1519892 URI
024	7	a https://doi.org/10.1159/0004918192 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Sigurdardottir, Gunnthorunn,d 1975-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center4 aut0 (Swepub:liu)gunsi16
245	1 0	a Decreased Systemic Levels of Endocan-1 and CXCL16 in Psoriasis Are Restored following Narrowband UVB Treatment.
264		c 2018-09-03
264	1	a Basel :b S. Karger,c 2018
338		a electronic2 rdacarrier
500		a This research was funded by the Ingrid Asp Foundation, the Welander Foundation, the Swedish Psoriasis Association, and the Medical Research Council.
520		a BACKGROUND: In psoriasis, a common immune-mediated disease affecting 2-3% of the population worldwide, there is an increased prevalence of extracutaneous diseases including obesity, the metabolic syndrome, and cardiovascular disease. This is believed to be linked to systemic inflammation. In previous studies, we have explored various markers in plasma and serum to characterize the ongoing systemic inflammation in psoriasis patients compared to controls. We have identified several markers that were altered in psoriasis patients, but which all were unresponsive to narrowband UVB (NB-UVB) treatment.OBJECTIVE: The objective of the study was to evaluate the effect of NB-UVB treatment on markers of cardiovascular risk and systemic inflammation in psoriasis.METHODS: The levels of 17 potential biomarkers with an association with cardiovascular risk were quantitated in plasma from 37 age- and gender-matched psoriasis patients and controls at baseline and in 21 psoriasis patients after 12 weeks of NB-UVB treatment to identify a systemic treatment response.RESULTS: We identified the mediators endocan-1, CXCL16, and sVEGFR1, which were systemically decreased in psoriasis at baseline, as well as FABP3, FABP4, and sIL-1R1, which showed normal baseline levels. After 10-12 weeks of NB-UVB treatment, endocan-1 and CXCL16 were restored to normal levels, while sVEGFR1, FABP3, FABP4, and sIL-1R1 showed a significant reduction.CONCLUSION: The current study expands the number of potential biomarkers in psoriasis by including a greater number and variety of mediators, approaching the systemic inflammation from additional vantage points, including soluble immune receptors and adipocyte contribution, to provide a more complete picture of the systemic inflammatory state in psoriasis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
653		a Cardiovascular risk
653		a Psoriasis
653		a Skin
653		a UVB
700	1	a Ekman, Anna-Karin,d 1981-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Center4 aut0 (Swepub:liu)annek78
700	1	a Verma, Deepti,d 1969-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Center4 aut0 (Swepub:liu)deeve22
700	1	a Enerbäck, Charlotta,d 1965-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center4 aut0 (Swepub:liu)chaen00
710	2	a Linköpings universitetb Avdelningen för cellbiologi4 org
773	0	t Dermatologyd Basel : S. Kargerg 234:5-6, s. 173-179q 234:5-6<173-179x 1018-8665x 1421-9832
856	4	u https://liu.diva-portal.org/smash/get/diva2:1255438/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
856	4	u http://liu.diva-portal.org/smash/get/diva2:1255438/FULLTEXT01
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151989
856	4 8	u https://doi.org/10.1159/000491819

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