WFRF:(Eriksen J)
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- Karlsson, JLinköpings universitet,Hälsouniversitetet,Farmakologi (author)
Cardioprotective effects of the MR contrast agent MnDPDP and its metabolite MnPLED upon reperfusion of the ischemic porcine myocardium
- Article/chapterEnglish2001
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- 2001
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-26972
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-26972URI
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- Language:English
- Summary in:English
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- Purpose: To evaluate whether manganese dipyridoxyl diphosphate (MnDPDP) or its metabolite manganese dipyridoxyl ethyldiamine (MnPLED) reduces post-ischemic myocardial injury. Material and Methods: Left anterior descending artery (LAD) in anesthetized pigs was occluded (30 min) followed by reperfusion (120 min) during hemodynamic monitoring and infarct assessment. Three ╡mol/kg MnDPDP, 1 ╡mol/kg MnPLED (or a mixture of both) or saline was injected i.v. 10 min before reperfusion followed by infusion of either 3 ╡mol/kg/h MnDPDP, 1 ╡mol/kg/h MnPLED (or a mixture of both) or saline. The plasma concentrations of MnDPDP, MnPLED and other metabolites (e.g., ZnDPDP and ZnPLED) were analyzed. Results: Femoral blood flow was reduced by 60% during early reperfusion in controls, whereas only 23 and 31% reductions were seen in animals treated with MnDPDP and MnPLED During that time, +LV/dP and -LV/dP (maximum rate of left ventricular isovolumic contraction and relaxation, respectively), systolic pressure and diastolic pressure fell significantly less in animals treated with MnDPDP or MnPLED. Three out of 5 control animals experienced ventricular fibrillation (VF) during reperfusion, whereas VF was not seen in any of the pigs treated with MnPLED or/and MnDPDP. The infarct sizes in saline- and MnPLED-treated animals were 39▒6 and 16▒5%, respectively, of the occluded areas. MnDPDP did not reduce the infarct size. A mixture of MnDPDP and MnPLED significantly reduced infarct size (10▒4%). When reperfusion started and throughout reperfusion, almost all injected MnDPDP was present as Zn-metabolites. Conclusion: MnPLED seems to reduce reperfusion-induced cardiac dysfunction and infarct size in pigs. MnDPDP does not reduce infarct size in the pig, probably because of the rapid exchange of Mn2+ for Zn2+ taking place in the pig.
Subject headings and genre
- MEDICINE
- MEDICIN
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- Brurok, KTrondheim (author)
- Eriksen, MOslo (author)
- Towart, RUSA (author)
- Toft, KOslo (author)
- Moen, OOslo (author)
- Engebretsen, BOslo (author)
- Jynge, PTrondheim (author)
- Refsum, HOslo (author)
- Linköpings universitetHälsouniversitetet (creator_code:org_t)
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- In:Acta Radiologica42:6, s. 540-5470284-18511600-0455
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- Jynge, P
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