The abdominoperineal resection itself is associated with an adverse outcome: The European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Folkesson J.) > The abdominoperinea...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		02920naa a2200445 4500
001		oai:DiVA.org:uu-98438
003		SwePub
008		090223s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-984382 URI
024	7	a https://doi.org/10.1016/j.ejca.2008.11.0392 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a den Dulk, Marcel4 aut
245	1 0	a The abdominoperineal resection itself is associated with an adverse outcome :b The European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer
264	1	b Elsevier BV,c 2009
338		a print2 rdacarrier
520		a PURPOSE: The aim of this study is to identify factors associated with the decision to perform an abdominoperineal resection (APR) and to assess if these factors or the surgical procedure itself is associated with circumferential resection margin (CRM) involvement, local recurrence (LR), overall survival (OS) and cancer-specific survival (CSS). PATIENTS AND METHODS: The Swedish Rectal Cancer Trial (SRCT), TME trial, CAO/ARO/AIO-94 trial, EORTC 22921 trial and Polish Rectal Cancer Trial (PRCT) were pooled. A propensity score was calculated, which indicated the predicted probability of undergoing an APR given gender, age and distance, and used in the multivariate analyses. RESULTS: An APR procedure was associated with an increased risk of CRM involvement [odd ratio (OR) 2.52, p<0.001], increased LR rate [hazard ratio (HR) 1.53, p=0.001] and decreased CSS rate (HR 1.31, p=0.002), whereas the propensity score was not. CONCLUSION: The results suggest that the APR procedure itself is a significant predictor for non-radical resections and increased risk of LR and death due to cancer for patients with advanced rectal cancer.
653		a Rectal cancer
653		a Surgical procedure
653		a Abdominoperineal resection
653		a Circumferential resection margin
653		a Local recurrence
653		a MEDICINE
653		a MEDICIN
700	1	a Putter, Hein4 aut
700	1	a Collette, Laurence4 aut
700	1	a Marijnen, Corrie A. M.4 aut
700	1	a Folkesson, Joakimu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)jofol839
700	1	a Bosset, Jean-Francois4 aut
700	1	a Rödel, Claus4 aut
700	1	a Bujko, Krzysztof4 aut
700	1	a Påhlman, Larsu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)larspahl
700	1	a van de Velde, Cornelis J. H.4 aut
710	2	a Uppsala universitetb Kolorektalkirurgi4 org
773	0	t European Journal of Cancerd : Elsevier BVg 45:7, s. 1175-1183q 45:7<1175-1183x 0959-8049x 1879-0852
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98438
856	4 8	u https://doi.org/10.1016/j.ejca.2008.11.039

Hitta via bibliotek

European Journal of Cancer (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: den Dulk, Marcel; Putter, Hein; Collette, Lauren ...; Marijnen, Corrie ...; Folkesson, Joaki ...; Bosset, Jean-Fra ...; visa fler...; Rödel, Claus; Bujko, Krzysztof; Påhlman, Lars; van de Velde, Co ...; visa färre...

Artiklar i publikationen: European Journal ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se