Interaction between Shift Work and Established Coronary Risk Factors

BACKGROUND: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work.OBJECTIVE: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction.METHODS: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis.RESULTS: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38).CONCLUSION: Shift work and some established coronary risk factors have significant interactions.

Bøggild, HenrikAalborg Univ, Dept Hlth Sci & Technol, Publ Hlth & Epidemiol Grp, Aalborg, Denmark (författare)
Hallqvist, Johan,1950-Uppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)johha694 (författare)
Karlsson, BerndtUmeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Occupat Med, Umea, Sweden(Swepub:umu)beka0011 (författare)
Knutsson, Anders,1942-Mittuniversitetet,Institutionen för hälsovetenskap,Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden(Swepub:miun)andknu (författare)
Nilsson, Tohr,1948-Department of Occupational and Environmental Medicine, Sundsvall Hospital, Sundsvall, Sweden.,Sundsvall Hosp, Dept Occupat & Environm Med, Sundsvall, Sweden(Swepub:umu)toni0008 (författare)
Reuterwall, ChristinaUmeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Occupat Med, Umea, Sweden(Swepub:umu)chre0013 (författare)
Gillander Gådin, Katja,1960-Mittuniversitetet,Institutionen för hälsovetenskap,Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden(Swepub:miun)katgil (författare)
Angered Hosp, POB 63, S-42422 Angered, SwedenAalborg Univ, Dept Hlth Sci & Technol, Publ Hlth & Epidemiol Grp, Aalborg, Denmark (creator_code:org_t)

Ingår i:International Journal of Occupational and Environmental Medicine: IJOEM10:2, s. 57-652008-65202008-6814

Av författaren/redakt...: Hermansson, Jona ...; Bøggild, Henrik; Hallqvist, Johan ...; Karlsson, Berndt; Knutsson, Anders ...; Nilsson, Tohr, 1 ...; visa fler...; Reuterwall, Chri ...; Gillander Gådin, ...; visa färre...

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