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  • Gomez-Gallego, F (author)

Are elite endurance athletes genetically predisposed to lower disease risk?

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • American Physiological Society,2010

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:120130072
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:120130072URI
  • https://doi.org/10.1152/physiolgenomics.00183.2009DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We compared a polygenic profile that combined 33 disease risk-related mutations and polymorphisms among nonathletic healthy control subjects and elite endurance athletes. The study sample comprised 100 healthy Spanish male nonathletic (sedentary) control subjects and 100 male elite endurance athletes. We analyzed 33 disease risk-related mutations and polymorphisms. We computed a health-related total genotype score (TGS, 0–100) from the accumulated combination of the 33 variants. We did not observe significant differences in genotype or allele distributions among groups, except for the rs4994 polymorphism ( P < 0.001). The computed health-related TGS was similar among groups (23.8 ± 1.0 vs. 24.2 ± 0.8 in control subjects and athletes, respectively; P = 0.553). Similar results were obtained when computing specific TGSs for each main disease category (cardiovascular disease and cancer). We observed no evidence that male elite endurance athletes are genetically predisposed to have lower disease risk than matched nonathletic control subjects.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ruiz, JRKarolinska Institutet (author)
  • Buxens, A (author)
  • Altmae, SKarolinska Institutet (author)
  • Artieda, M (author)
  • Santiago, C (author)
  • Gonzalez-Freire, M (author)
  • Verde, Z (author)
  • Arteta, D (author)
  • Martinez, A (author)
  • Tejedor, D (author)
  • Lao, JI (author)
  • Arenas, J (author)
  • Lucia, A (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Physiological genomics: American Physiological Society41:1, s. 82-901531-22671094-8341

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