WFRF:(Lao S)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02497naa a2200397 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:120130072 | |
| 003 | SwePub | |
| 008 | 240811s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1201300722 URI |
| 024 | 7 | a https://doi.org/10.1152/physiolgenomics.00183.20092 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gomez-Gallego, F4 aut |
| 245 | 1 0 | a Are elite endurance athletes genetically predisposed to lower disease risk? |
| 264 | 1 | b American Physiological Society,c 2010 |
| 520 | a We compared a polygenic profile that combined 33 disease risk-related mutations and polymorphisms among nonathletic healthy control subjects and elite endurance athletes. The study sample comprised 100 healthy Spanish male nonathletic (sedentary) control subjects and 100 male elite endurance athletes. We analyzed 33 disease risk-related mutations and polymorphisms. We computed a health-related total genotype score (TGS, 0–100) from the accumulated combination of the 33 variants. We did not observe significant differences in genotype or allele distributions among groups, except for the rs4994 polymorphism ( P < 0.001). The computed health-related TGS was similar among groups (23.8 ± 1.0 vs. 24.2 ± 0.8 in control subjects and athletes, respectively; P = 0.553). Similar results were obtained when computing specific TGSs for each main disease category (cardiovascular disease and cancer). We observed no evidence that male elite endurance athletes are genetically predisposed to have lower disease risk than matched nonathletic control subjects. | |
| 700 | 1 | a Ruiz, JRu Karolinska Institutet4 aut |
| 700 | 1 | a Buxens, A4 aut |
| 700 | 1 | a Altmae, Su Karolinska Institutet4 aut |
| 700 | 1 | a Artieda, M4 aut |
| 700 | 1 | a Santiago, C4 aut |
| 700 | 1 | a Gonzalez-Freire, M4 aut |
| 700 | 1 | a Verde, Z4 aut |
| 700 | 1 | a Arteta, D4 aut |
| 700 | 1 | a Martinez, A4 aut |
| 700 | 1 | a Tejedor, D4 aut |
| 700 | 1 | a Lao, JI4 aut |
| 700 | 1 | a Arenas, J4 aut |
| 700 | 1 | a Lucia, A4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Physiological genomicsd : American Physiological Societyg 41:1, s. 82-90q 41:1<82-90x 1531-2267x 1094-8341 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120130072 |
| 856 | 4 8 | u https://doi.org/10.1152/physiolgenomics.00183.2009 |
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