Nerve growth factor in the equine joint

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Lindahl Elisabeth) > Nerve growth factor...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		05018naa a2200613 4500
001		oai:gup.ub.gu.se/301408
003		SwePub
008		240528s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:slubar.slu.se:110279
024	7	a https://gup.ub.gu.se/publication/3014082 URI
024	7	a https://doi.org/10.1016/j.tvjl.2020.1055792 DOI
024	7	a https://res.slu.se/id/publ/1102792 URI
040		a (SwePub)gud (SwePub)slu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kendall, Annau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health4 aut0 (Swepub:slu)51201
245	1 0	a Nerve growth factor in the equine joint
264	1	b Elsevier BV,c 2021
520		a Nerve growth factor (NGF) is a neurotrophin with many functions. In humans, it is involved in inflammation, nerve growth, apoptosis and pain signalling. Increased concentrations of NGF in synovial fluid has been shown in humans and dogs with osteoarthritis. Despite osteoarthritis being a common problem in horses, no studies have previously been published on NGF in the equine joint. The aim of this study was to quantify NGF in equine synovial fluid from healthy joints, acutely inflamed septic joints and joints with structural changes associated with osteoarthritis. A secondary aim was to identify the localisation of NGF and its two receptors, TrkA and p75(NTR) in healthy and osteoarthritic articular cartilage. NGF concentrations in synovial fluid from osteoarthritic joints (n = 27), septic joints (n = 9) and healthy joints (n = 16) were determined by ELISA. In addition, articular cartilage from osteoarthritic and healthy joints was examined for NGF, TrkA and P75(NTR) using immunohistochemistry staining. NGF was present in equine synovial fluid and articular cartilage. Compared to synovial fluid from healthy joints, NGF concentration was higher in synovial fluid from joints with structural osteoarthritic changes (P = 0.032) or acute septic inflammation (P = 0.006). In articular cartilage with severe osteoarthritic changes, there was more abundant positive immunohistochemistry staining for NGF and its receptors than in normal articular cartilage. Further studies should focus on identifying precursor forms of NGF, and on receptor expression and downstream signalling of TrkA and P75(NTR) in health and disease. (C) 2020 The Author(s). Published by Elsevier Ltd.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650	7	a LANTBRUKSVETENSKAPERx Veterinärmedicinx Patobiologi0 (SwePub)403022 hsv//swe
650	7	a AGRICULTURAL SCIENCESx Veterinary Sciencex Pathobiology0 (SwePub)403022 hsv//eng
653		a Horse
653		a Joint
653		a Nerve
653		a Growth factor
653		a Osteoarthritis
653		a swedish horses
653		a pain
653		a osteoarthritis
653		a survival
653		a prongf
653		a breed
653		a knee
653		a dogs
653		a sex
653		a age
653		a Veterinary Sciences
700	1	a Ekman, Stinau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health4 aut0 (Swepub:slu)47073
700	1	a Mattsson Hultén, Lillemor,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmatli
700	1	a Lindahl, A.4 aut
700	1	a Hansson, Elisabeth,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xhanse
700	1	a Skiöldebrand, Evau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health4 aut0 (Swepub:slu)50022
710	2	a Sveriges lantbruksuniversitetb Inst för biomedicin och veterinär folkhälsovetenskap4 org
710	2	a Sveriges lantbruksuniversitet
773	0	t Veterinary Journald : Elsevier BVg 267q 267x 1090-0233x 1532-2971
856	4	u https://doi.org/10.1016/j.tvjl.2020.105579
856	4	u https://pub.epsilon.slu.se/id/eprint/22797/contentsx primaryx Raw objectx freey FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/301408
856	4 8	u https://doi.org/10.1016/j.tvjl.2020.105579
856	4 8	u https://res.slu.se/id/publ/110279

Hitta via bibliotek

Veterinary Journal (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Kendall, Anna; Ekman, Stina; Mattsson Hultén, ...; Lindahl, A.; Hansson, Elisabe ...; Skiöldebrand, Ev ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

LANTBRUKSVETENSKAPER: LANTBRUKSVETENSK ...; och Veterinärmedicin; och Patobiologi

Artiklar i publikationen: Veterinary Journ ...

Av lärosätet: Göteborgs universitet; Sveriges Lantbruksuniversitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se