Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

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Fältnamn	Indikatorer	Metadata
000		10072naa a2201825 4500
001		oai:gup.ub.gu.se/152191
003		SwePub
008		240528s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:c38f2e29-1e58-4f8a-958b-3444b1ecb511
009		oai:DiVA.org:umu-51101
009		oai:prod.swepub.kib.ki.se:123902905
024	7	a https://gup.ub.gu.se/publication/1521912 URI
024	7	a https://doi.org/10.1371/journal.pmed.10011162 DOI
024	7	a https://lup.lub.lu.se/record/23481742 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-511012 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1239029052 URI
040		a (SwePub)gud (SwePub)lud (SwePub)umud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kilpeläinen, Tuomas O4 aut
245	1 0	a Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
264		c 2011-11-01
264	1	b Public Library of Science (PLoS),c 2011
520		a BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) =0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio =1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio =1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700	1	a Qi, Lu4 aut
700	1	a Brage, Soren4 aut
700	1	a Sharp, Stephen J4 aut
700	1	a Sonestedt, Emilyu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-eso
700	1	a Demerath, Ellen4 aut
700	1	a Ahmad, Tariq4 aut
700	1	a Mora, Samia4 aut
700	1	a Kaakinen, Marika4 aut
700	1	a Sandholt, Camilla Helene4 aut
700	1	a Holzapfel, Christina4 aut
700	1	a Autenrieth, Christine S4 aut
700	1	a Hyppönen, Elina4 aut
700	1	a Cauchi, Stéphane4 aut
700	1	a He, Meian4 aut
700	1	a Kutalik, Zoltan4 aut
700	1	a Kumari, Meena4 aut
700	1	a Stančáková, Alena4 aut
700	1	a Meidtner, Karina4 aut
700	1	a Balkau, Beverley4 aut
700	1	a Tan, Jonathan T4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Timpson, Nicholas J4 aut
700	1	a Song, Yiqing4 aut
700	1	a Zillikens, M Carola4 aut
700	1	a Jablonski, Kathleen A4 aut
700	1	a Garcia, Melissa E4 aut
700	1	a Johansson, Stefan4 aut
700	1	a Bragg-Gresham, Jennifer L4 aut
700	1	a Wu, Ying4 aut
700	1	a van Vliet-Ostaptchouk, Jana V4 aut
700	1	a Onland-Moret, N Charlotte4 aut
700	1	a Zimmermann, Esther4 aut
700	1	a Rivera, Natalia V4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Stringham, Heather M4 aut
700	1	a Silbernagel, Günther4 aut
700	1	a Kanoni, Stavroula4 aut
700	1	a Feitosa, Mary F4 aut
700	1	a Snitker, Soren4 aut
700	1	a Ruiz, Jonatan Ru Karolinska Institutet4 aut
700	1	a Metter, Jeffery4 aut
700	1	a Larrad, Maria Teresa Martinez4 aut
700	1	a Atalay, Mustafa4 aut
700	1	a Hakanen, Maarit4 aut
700	1	a Amin, Najaf4 aut
700	1	a Cavalcanti-Proença, Christine4 aut
700	1	a Grøntved, Anders4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo
700	1	a Kuusisto, Johanna4 aut
700	1	a Kähönen, Mika4 aut
700	1	a Lutsey, Pamela L4 aut
700	1	a Nolan, John J4 aut
700	1	a Palla, Luigi4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Pérusse, Louis4 aut
700	1	a Renström, Fridau Umeå universitet,Medicin4 aut0 (Swepub:umu)frre0001
700	1	a Scott, Robert A4 aut
700	1	a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)dmsh0003
700	1	a Sovio, Ulla4 aut
700	1	a Tammelin, Tuija H4 aut
700	1	a Rönnemaa, Tapani4 aut
700	1	a Lakka, Timo A4 aut
700	1	a Uusitupa, Matti4 aut
700	1	a Rios, Manuel Serrano4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Bouchard, Claude4 aut
700	1	a Meirhaeghe, Aline4 aut
700	1	a Fu, Mao4 aut
700	1	a Walker, Mark4 aut
700	1	a Borecki, Ingrid B4 aut
700	1	a Dedoussis, George V4 aut
700	1	a Fritsche, Andreas4 aut
700	1	a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xohlcl
700	1	a Boehnke, Michael4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Ebrahim, Shah4 aut
700	1	a Lawlor, Debbie A4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Harris, Tamara B4 aut
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Hofman, Albert4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Njølstad, Pål R4 aut
700	1	a Florez, Jose C4 aut
700	1	a Liu, Simin4 aut
700	1	a Ness, Andy4 aut
700	1	a Spector, Timothy D4 aut
700	1	a Tai, E Shyong4 aut
700	1	a Froguel, Philippe4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Laakso, Markku4 aut
700	1	a Marmot, Michael4 aut
700	1	a Bergmann, Sven4 aut
700	1	a Power, Chris4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Chasman, Daniel4 aut
700	1	a Ridker, Paul4 aut
700	1	a Hansen, Torben4 aut
700	1	a Monda, Keri L4 aut
700	1	a Illig, Thomas4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Hu, Frank B4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Ekelund, Ulf4 aut
700	1	a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)pafr0003
700	1	a Loos, Ruth J F4 aut
710	2	a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org
773	0	t PLoS medicined : Public Library of Science (PLoS)g 8:11q 8:11x 1549-1676x 1549-1277
856	4	u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001116&type=printable
856	4	u https://portal.research.lu.se/files/2386162/2544341.pdfx primaryx freey FULLTEXT
856	4	u http://dx.doi.org/10.1371/journal.pmed.1001116y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/152191
856	4 8	u https://doi.org/10.1371/journal.pmed.1001116
856	4 8	u https://lup.lub.lu.se/record/2348174
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51101
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123902905

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Av författaren/redakt...: Kilpeläinen, Tuo ...; Qi, Lu; Brage, Soren; Sharp, Stephen J; Sonestedt, Emily; Demerath, Ellen; visa fler...; Ahmad, Tariq; Mora, Samia; Kaakinen, Marika; Sandholt, Camill ...; Holzapfel, Chris ...; Autenrieth, Chri ...; Hyppönen, Elina; Cauchi, Stéphane; He, Meian; Kutalik, Zoltan; Kumari, Meena; Stančáková, Alen ...; Meidtner, Karina; Balkau, Beverley; Tan, Jonathan T; Mangino, Massimo; Timpson, Nichola ...; Song, Yiqing; Zillikens, M Car ...; Jablonski, Kathl ...; Garcia, Melissa ...; Johansson, Stefa ...; Bragg-Gresham, J ...; Wu, Ying; van Vliet-Ostapt ...; Onland-Moret, N ...; Zimmermann, Esth ...; Rivera, Natalia ...; Tanaka, Toshiko; Stringham, Heath ...; Silbernagel, Gün ...; Kanoni, Stavroul ...; Feitosa, Mary F; Snitker, Soren; Ruiz, Jonatan R; Metter, Jeffery; Larrad, Maria Te ...; Atalay, Mustafa; Hakanen, Maarit; Amin, Najaf; Cavalcanti-Proen ...; Grøntved, Anders; Hallmans, Göran; Jansson, John-Ol ...; Kuusisto, Johann ...; Kähönen, Mika; Lutsey, Pamela L; Nolan, John J; Palla, Luigi; Pedersen, Oluf; Pérusse, Louis; Renström, Frida; Scott, Robert A; Shungin, Dmitry; Sovio, Ulla; Tammelin, Tuija ...; Rönnemaa, Tapani; Lakka, Timo A; Uusitupa, Matti; Rios, Manuel Ser ...; Ferrucci, Luigi; Bouchard, Claude; Meirhaeghe, Alin ...; Fu, Mao; Walker, Mark; Borecki, Ingrid ...; Dedoussis, Georg ...; Fritsche, Andrea ...; Ohlsson, Claes, ...; Boehnke, Michael; Bandinelli, Stef ...; van Duijn, Corne ...; Ebrahim, Shah; Lawlor, Debbie A; Gudnason, Vilmun ...; Harris, Tamara B; Sørensen, Thorki ...; Mohlke, Karen L; Hofman, Albert; Uitterlinden, An ...; Tuomilehto, Jaak ...; Lehtimäki, Terho; Raitakari, Olli; Isomaa, Bo; Njølstad, Pål R; Florez, Jose C; Liu, Simin; Ness, Andy; Spector, Timothy ...; Tai, E Shyong; Froguel, Philipp ...; Boeing, Heiner; Laakso, Markku; Marmot, Michael; Bergmann, Sven; Power, Chris; Khaw, Kay-Tee; Chasman, Daniel; Ridker, Paul; Hansen, Torben; Monda, Keri L; Illig, Thomas; Järvelin, Marjo- ...; Wareham, Nichola ...; Hu, Frank B; Groop, Leif; Orho-Melander, M ...; Ekelund, Ulf; Franks, Paul; Loos, Ruth J F; visa färre...

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