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Erythroid induction...
Erythroid induction activity of Aquilegia fragrans and Aquilegia pubiflora and identification of compounds using liquid chromatography-tandem mass spectrometry
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- Aziz, Nudrat (författare)
- Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
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- Khan, Muhammad Noman (författare)
- Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
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- Ul Haq, Faraz (författare)
- Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
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- Ahmed, Fayaz (författare)
- Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
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- Ali, Arslan (författare)
- Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.
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- Musharraf, Syed Ghulam (författare)
- Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Southwest Med Univ, TCM Hosp, Luzhou, Sichuan, Peoples R China.
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Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: JOURNAL OF KING SAUD UNIVERSITY SCIENCE. - : Elsevier. - 1018-3647 .- 2213-686X. ; 33:1
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Abstract
Ämnesord
Stäng
- Aquilegia fragrans (AF) and Aquilegia pubiflora (AP) are the two medicinally important species of genus Aquilegia used for the treatment of various diseases and infections. This paper describes the potential of fetal hemoglobin induction activity of the methanolic extracts of AF and AP in K562 cell line. AF and AP have shown 27.147 +/- 1.376 and 32.786 +/- 1.048 percent erythroid induction, respectively at 15.625 (mg/mL) concentration which suggested that both plants can be the source of potential fetal hemoglobin inducers and may be used for the treatment of beta-thalassemia. Phytochemical analyses of both species were also evaluated by using high-resolution LC-ESI-QTOF-MS/MS techniques. A Total of thirty compounds were identified using positive and negative ionization modes. The identification was based on the matching of high-resolution masses, isotopic pattern, and MS/MS fragmentation. Several statistical analyses were performed to evaluate the distribution of compounds in both species. Identified compounds belong to various classes including flavonoids, steroids, lignans, terpenoids, benzofuran and coumarins. The established chemical fingerprints will be helpful in standardization and quality control of plant extracts.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Aquilegia pubiflora
- Aquilegia fragrans
- beta-thalassemia
- Fetal hemoglobin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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