Sökning: WFRF:(Sorokin Lydia) > Localization of lam...
Fältnamn | Indikatorer | Metadata |
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000 | 03902naa a2200529 4500 | |
001 | oai:DiVA.org:umu-82687 | |
003 | SwePub | |
008 | 131106s2002 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1939117 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-826872 URI |
024 | 7 | a https://doi.org/10.1177/0022155402050008132 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19391172 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Petäjäniemi, Noorau University of Helsinki4 aut |
245 | 1 0 | a Localization of laminin alpha4-chain in developing and adult human tissues |
264 | c 2016-06-26 | |
264 | 1 | b SAGE Publications,c 2002 |
338 | a print2 rdacarrier | |
520 | a Recent studies suggest important functions for laminin-8 (Ln-8; alpha4beta1gamma1) in vascular and blood cell biology, but its distribution in human tissues has remained elusive. We have raised a monoclonal antibody (MAb) FC10, and by enzyme-linked immunoassay (EIA) and Western blotting techniques we show that it recognizes the human Ln alpha4-chain. Immunoreactivity for the Ln alpha4-chain was localized in tissues of mesodermal origin, such as basement membranes (BMs) of endothelia, adipocytes, and skeletal, smooth, and cardiac muscle cells. In addition, the Ln alpha4-chain was found in regions of some epithelial BMs, including epidermis, salivary glands, pancreas, esophageal and gastric glands, intestinal crypts, and some renal medullary tubules. Developmental differences in the distribution of Ln alpha4-chain were detected in skeletal muscle, walls of vessels, and intestinal crypts. Ln alpha4- and Ln alpha2-chains co-localized in BMs of fetal skeletal muscle cells and in some epithelial BMs, e.g., in gastric glands and acini of pancreas. Cultured human pulmonary artery endothelial (HPAE) cells produced Ln alpha4-chain as M(r) 180,000 and 200,000 doublet and rapidly deposited it to the growth substratum. In cell-free extracellular matrices of human kidney and lung, Ln alpha4-chain was found as M(r) 180,000 protein. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a basement membrane | |
653 | a laminin-8 | |
653 | a alpha 4-chain | |
653 | a monoclonal antibody | |
653 | a endothelial cell | |
700 | 1 | a Korhonen, Mattiu Helsinki University Central Hospital4 aut |
700 | 1 | a Kortesmaa, Jarkkou Karolinska Institute and BioStratum AB, Stockholm4 aut |
700 | 1 | a Tryggvason, Karlu Karolinska Institutet4 aut |
700 | 1 | a Sekiguchi, Kiyotoshiu Osaka University4 aut |
700 | 1 | a Fujiwara, Hironobuu Osaka University4 aut |
700 | 1 | a Sorokin, Lydiau IZKF Nachwuchsgruppe II, Nikolaus Fiebiger Center, Erlangen, Germany4 aut |
700 | 1 | a Thornell, Lars-Ericu Umeå universitet,Anatomi4 aut0 (Swepub:umu)lath0002 |
700 | 1 | a Wondimu, Zenebechu Karolinska Institute4 aut |
700 | 1 | a Assefa, Danielu Karolinska Institute4 aut |
700 | 1 | a Patarroyo, Manuelu Karolinska Institutet4 aut |
700 | 1 | a Virtanen, Ismou University of Helsinki4 aut |
710 | 2 | a University of Helsinkib Helsinki University Central Hospital4 org |
773 | 0 | t Journal of Histochemistry and Cytochemistryd : SAGE Publicationsg 50:8, s. 1113-1130q 50:8<1113-1130x 0022-1554x 1551-5044 |
856 | 4 | u https://journals.sagepub.com/doi/pdf/10.1177/002215540205000813 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82687 |
856 | 4 8 | u https://doi.org/10.1177/002215540205000813 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1939117 |
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