Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

Iversen, AKN (författare)

Christiansen, CB (författare)

Attermann, J (författare)

Eugen-Olsen, J (författare)

Schulman, S (författare)

Berntorp, Erik (författare): Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups

Ingerslev, J (författare)

Fugger, L (författare)

Scheibel, E (författare)

Tengborn, Lilian (författare): Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Coagulation, Malmö,Lund University Research Groups

Gerstoft, J (författare)

Dickmeiss, E (författare)

Svejgaard, A (författare)

Skinhoj, P (författare)

(creator_code:org_t)

Relaterad länk:: http://ucp.uchicago....; visa fler...; https://lup.lub.lu.s...; visa färre...

Abstract Ämnesord

Stäng

The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.

Av författaren/redakt...: Iversen, AKN; Christiansen, CB; Attermann, J; Eugen-Olsen, J; Schulman, S; Berntorp, Erik; visa fler...; Ingerslev, J; Fugger, L; Scheibel, E; Tengborn, Lilian; Gerstoft, J; Dickmeiss, E; Svejgaard, A; Skinhoj, P; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.